In order to enhance the high-temperature mechanical performance to meet service requirements, the microstructures and tensile properties of heat-treated Al-8.4Cu-2.3Ce-1.0Mn-0.2Zr-xNi (x = 0, 0.5, 1.0, 2.0, 4.0 wt.%) were investigated. The metallographic analysis techniques have been used to examine the microstructural changes with different Ni contents. Results show that after adding 0.5% Ni to the Al-8.4Cu-2.3Ce-1.0Mn-0.2Zr alloy, the spheroidized Al₇Cu₄Ni phase is formed. With Ni content further increasing, the Al₈CeCu₄ and Al₂₄MnCu₈Ce₃ phases disappear, and the nano-sized Al₂₀Cu₂Mn₃ and Al₂Cu phases decrease gradually. When Ni content reaches 4.0%, the Al₃CuNi phase appears. It turns out that the addition of 0.5% Ni has significantly improved the tensile properties at 400 °C. The ultimate tensile strength, yield strength, and elongation of Al-8.4Cu-2.3Ce-1.0Mn-0.2Zr-0.5Ni alloy at 400 °C reach 103 MPa, 93 Mpa, and 18.0%, respectively, which makes the alloy possible to be employed at 400 °C. The intermetallic micro-skeleton, composed of thermostable Al₈CeCu₄, Al₂₄MnCu₈Ce₃, Al₁₆Cu₄Mn₂Ce, and Al₇Cu₄Ni phases at the grain boundaries as well as nano-sized Al₂₀Cu₂Mn₃ and Al₂Cu precipitates in the grains, contributes to the good elevated-temperature tensile strength. The fracture mechanism is changed from quasi-cleavage at ambient temperature to coexistence of quasi-cleavage and dimple at 400 °C.