Veterinary Research, a journal on Animal Infection

Paratuberculosis, a chronic disease affecting ruminant livestock, is caused by Mycobacterium avium subsp. paratuberculosis (MAP). It has direct and indirect economic costs, impacts animal welfare and arouses public health concerns. In a survey of 48 countries we found paratuberculosis to be very common in livestock. In about half the countries more than 20% of herds and flocks were infected with MAP. Most countries had large ruminant populations (millions), several types of farmed ruminants, multiple husbandry systems and tens of thousands of individual farms, creating challenges for disease control. In addition, numerous species of free-living wildlife were infected. Paratuberculosis was notifiable in most countries, but formal control programs were present in only 22 countries. Generally, these were the more highly developed countries with advanced veterinary services. Of the countries without a formal control program for paratuberculosis, 76% were in South and Central America, Asia and Africa while 20% were in Europe. Control programs were justified most commonly on animal health grounds, but protecting market access and public health were other factors. Prevalence reduction was the major objective in most countries, but Norway and Sweden aimed to eradicate the disease, so surveillance and response were their major objectives. Government funding was involved in about two thirds of countries, but operations tended to be funded by farmers and their organizations and not by government alone. The majority of countries (60%) had voluntary control programs. Generally, programs were supported by incentives for joining, financial compensation and/or penalties for non-participation. Performance indicators, structure, leadership, practices and tools used in control programs are also presented. Securing funding for long-term control activities was a widespread problem. Control programs were reported to be successful in 16 (73%) of the 22 countries. Recommendations are made for future control programs, including a primary goal of establishing an international code for paratuberculosis, leading to universal acknowledgment of the principles and methods of control in relation to endemic and transboundary disease. An holistic approach across all ruminant livestock industries and long-term commitment is required for control of paratuberculosis.

Data from a survey performed from 1986 to 1990 were analyzed to assess the effects of diseases on length of productive life of 3589 Holstein cows from 47 herds, using a proportional hazard model. The probability of a cow being culled, or hazard function, was supposed to be the product of an unspecified baseline hazard function and log-linear, time-dependent explanatory variables that possibly influence culling rate (Cox's regression). The effect of 16 health events was studied according to lactation number of occurrence. The model included adjustments for effects of herd-year-season (considered to be random), month of calving, stage of lactation, lactation number, reproductive performance, and milk production. The probability of a cow being culled increased in early and late stages of lactation in older cows, in low producing cows, and in cows with poor reproductive performance. Mastitis before the peak of lactation or during the dry period increased the risk (relative culling rate in first lactation, 1.3 and 4.0, respectively). Teat injuries and nontraumatic udder disorders had a large impact on longevity. Cows with late metritis or early abortion had poor survival. The decrease in median length of productive life could be over a standard lactation in particular cases. Expected survivor curves, computed after assumption of a priori values of covariates and their evolution over time, appear to be powerful tools for examining the effect of health disorders on length of productive life of cows.