In the present study, the binding affinity of 52 bioactive secondary metabolites from Wedelia trilobata towards the anti-apoptotic B-cell lymphoma-2 (Bcl-2) protein (PDB: 2W3L) structure was identified by using in silico molecular docking and molecular dynamics simulation. The molecular docking results demonstrated that the binding energies of docked compounds with Bcl-2 protein ranged from −5.3 kcal/mol to −10.1 kcal/mol. However, the lowest binding energy (−10.1 kcal/mol) was offered by Friedelin against Bcl-2 protein when compared to other metabolites and the standard drug Obatoclax (−8.4 kcal/mol). The molecular dynamics simulations revealed that the Friedelin-Bcl-2 protein complex was found to be stable throughout the simulation period of 100 ns. Overall, the predicted Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) properties of Friedelin are relatively better than Obatoclax, with the most noticeable differences in many parameters where Friedelin has no AMES toxicity, hepatotoxicity, and skin sensitization. The ADMET profiling of selected compounds supported their in silico drug-likeness properties. Based on the computational analyses, the present study concluded that Friedelin of W. trilobata was found to be the potential inhibitor of the Bcl-2 protein, which merits attention for further in vitro and in vivo studies before clinical trials.

Background: Insulin resistance (IR) is a leading cause of the onset of Type 2 diabetes mellitus (T2DM) among overweight and obese individuals irrespective of their age. This study aimed at assessing the impact of 2 weeks of intensive integrated yoga therapy (IIYT) among overweight individuals diagnosed with T2DM identified with higher IR. Methodology: The current single-group longitudinal pre–post study enrolled adults (n = 30) from a residential health-care center, Bengaluru (India), who were subjected to IIYT, comprising practices at physical, emotional, and intellectual levels incorporating āsana (postures), prānāyāma (breathing exercise), kriyā (internal cleansing technique), meditation, notional correction, counseling, yogic diet, and devotional sessions. Pre- and postoutcome measures were homeostatic model assessment for IR (HOMA-IR), fasting serum insulin, lipid profile, body composition, and anthropometric measurements. Results: A significant reduction in HOMA-IR (35.69%, p < 0.001), fasting insulin (28%, p < 0.001), fasting glucose (12.3%, p = 0.039), triglycerides (15.43%, p = 0.003), very low-density lipoprotein (15.5%, p = 0.003), body mass index (2.4%, p < 0.001), weight (2.3%, p < 0.001), hip circumference (1.01%, p < 0.001), waist circumference (1.4%, p < 0.001), and body fat percentage (1.8%, p = 0.039) and a significant increase in lean mass percentage (0.95%, p = 0.045) and water percentage (0.99%, p = 0.04) were observed among the subjects. Conclusion: Regular practice of IIYT regulates lipid and anthropometric measures and increases lean body mass, thereby managing IR, among overweight Type 2 diabetes. However, future works might confirm the findings of the present study.

This case study discusses how a month-long, personalized yoga therapy program impacted a 57-year-old woman with lung cancer that had spread to her brain, who is currently receiving palliative care. Her yoga routine included gentle exercises (Sukshma Vyayama), breathing techniques (Pranayama), and meditation, which were suitable to fit her physical abilities. The Functional Assessment of Cancer Therapy-Lung (FACT-L) scale was used to measure her quality of life, revealing significant improvements in her well-being. She showed improvement in mobility, respiratory function, and emotional stability, as well as reduced lung cancer-related symptoms. Yoga's holistic approach not only supported her physical health but also enhanced her emotional and spiritual wellness, leading to a higher quality of life during her care. These results suggest that yoga therapy could be a valuable, non-invasive addition to palliative care, providing comfort and tailored support for patients with terminal illnesses.

Objectives: To determine the effect of Sookshma Meditation (SM) on Internet Addiction (IA), Emotional Regulation (ER), and Mindfulness in School Children- A randomized controlled trial. Methods: A randomized control trial designed to assess the effect of SM (Meditation-based Yoga practices) on IA, ER, and Mindfulness in school-going children. After screening, 80 school-going children (44 boys & 36 girls) with the age range of 12-14 years (13.37 0.69) were randomly assigned into two groups. Each group (Intervention & Control) contains 40 students. The intervention group had undergone the SM program daily for 30 minutes, 5 sessions per week, for four weeks. The control group followed day-to-day regular activities. Assessments were made before and after the 4-week program in two groups. Results: The result showed that IA was significantly reduced (P<0.001) in the intervention group, compared to the control group. A significant improvement is seen in ER strategies like cognitive reappraisal (P<0.001), expressive suppression (P=0.009), and mindfulness after the SM practice in the intervention group as compared to the control group. Conclusion: This study suggests that SM practice may be useful in reducing IA, enhancing ER, and mindfulness in school children. These findings need confirmation from studies with larger sample sizes with long term intervention. Keywords: Meditation, Yoga, Internet Addiction, Emotional Regulation, Mindfulness

Introduction: The COVID-19 pandemic has profoundly disrupted the lives of adolescents, leading to significant impacts on their physical and mental health. Adolescents are particularly vulnerable to psychological stress and anxiety, which can have long-term consequences on their well-being. By combining physical postures (Asanas), breathing practices (Pranayama), and meditation, yoga has been shown to improve both physical and mental health. This study investigates the effects of integrated yoga on mindfulness and mental well-being in adolescents during the postpandemic era. Methods: A randomized control trial was conducted with 80 adolescent participants, who were randomly allocated into yoga and control groups (1:1 ratio). The yoga group was given 60 min of integrated yoga, 6 days weekly for a month. Mindfulness, mental well-being, depression, anxiety, and stress along with anthropometric and vital parameters were assessed before and after the intervention. Results: The demographic characteristics of both groups were well-matched across gender, age, religion, and school type. We had one dropout in each group, we analyzed 39 in each group with 19 males and 20 females in both groups. The month long integrated yoga demonstrates significant improvement in mental well-being and mindfulness while it also reduced depression, anxiety, stress, and waist–hip ratio compared to the control group. However, it did not show any significant improvement in other anthropometry and vital parameters. Conclusion: The present study has examined the role of yoga in promoting the mental well-being and mindfulness of adolescents who experienced death or hospitalization of a family member during the COVID-19 pandemic period.