The water/graphene oxide nanofluid effect in a pipe equipped by twisted tape inserts under air cross-flow is investigated and the optimal tape geometry is determined. The range of internal and external Reynolds numbers are: 3800<Re_o<21500 and 550<Re_i<2000. Heat transfer and pressure drop increase by increasing Re and inserts width and heat transfer performance coefficient increased up to 1.4, indicating enhanced heat transfer compared to undesirable pressure drop. On the other hand, the heat transfer coefficient is 26% higher when compared with water in a plain tube. According to the results, this method is a good alternative in heat exchangers.