Recently, the preparation of smart multifunctional hybrid nanoparticles has captured significant interest in versatile areas, including medicine, environment, and food, due to their enhanced physicochemical properties. The present study focuses on the synthesis of Fe-doped NiO nanoparticles by the coprecipitation method using the sources of nickel (II) acetate tetrahydrate and iron (III) nitrate nonahydrate. The prepared Fe-doped NiO nanoparticles are characterized by X-ray diffraction, Fourier transform infrared spectroscopy, UV–visible spectroscopy, field-emission scanning electron microscopy, transmission electron microscopy, and X-ray photon spectroscopic analysis. The XRD results clearly confirm the face-centered cubic structure and polycrystalline nature of the synthesized Fe-NiO nanoparticles. The Tauc plot analysis revealed that the bandgap energy of the Fe-doped NiO nanoparticles decreased with the increasing concentration of the Fe dopant from 2% to 8%. The XPS analysis of the samples exhibited the existence of elements, including Fe, Ni, and O, with the absence of any surplus compounds. The FE-SEM and TEM analyses proved the formation of nanostructured Fe-NiO with few spherical and mostly unevenly shaped particles. Further, the photocatalytic efficiency of the prepared Fe-doped NiO nanoparticles were identified by using the cationic dye rhodamine B (Rh-B). The photocatalytic results proved the 8% of Fe doped with NiO nanoparticles achieved 99% of Rh-B degradation within 40 min of visible-light irradiation. Hence, the results of the present study exemplified the Fe-doped NiO nanoparticles have acted as a noticeable photocatalyst to degrade the Rh-B dye.

The present study investigates the brain-targeted efficiency of atomoxetine (AXT)-loaded nanostructured lipid carrier (NLC)-laden thermosensitive in situ gel after intranasal administration. AXT-NLC was prepared by the melt emulsification ultrasonication method and optimized using the Box–Behnken design (BBD). The optimized formulation (AXT-NLC) exhibited particle size PDI, zeta potential, and entrapment efficiency (EE) of 108 nm, 0.271, −42.3 mV, and 84.12%, respectively. The morphology of AXT-NLC was found to be spherical, as confirmed by SEM analysis. DSC results displayed that the AXT was encapsulated within the NLC matrix. Further, optimized NLC (AXT-NLC13) was incorporated into a thermosensitive in situ gel using poloxamer 407 and carbopol gelling agent and evaluated for different parameters. The optimized in situ gel (AXT-NLC13G4) formulation showed excellent viscosity (2532 ± 18 Cps) at 37 °C and formed the gel at 28–34 °C. AXT-NLC13-G4 showed a sustained release of AXT (92.89 ± 3.98% in 12 h) compared to pure AXT (95.47 ± 2.76% in 4 h). The permeation flux through goat nasal mucosa of AXT from pure AXT and AXT-NLC13-G4 was 504.37 µg/cm²·h and 232.41 µg/cm²·h, respectively. AXT-NLC13-G4 intranasally displayed significantly higher absolute bioavailability of AXT (1.59-fold higher) than intravenous administration. AXT-NLC13-G4 intranasally showed 51.91% higher BTP than pure AXT (28.64%) when administered via the same route (intranasally). AXT-NLC13-G4 showed significantly higher BTE (207.92%) than pure AXT (140.14%) when administered intranasally, confirming that a high amount of the AXT reached the brain. With the disrupted performance induced by L-methionine, the AXT-NLC13-G4 showed significantly (p < 0.05) better activity than pure AXT as well as donepezil (standard). The finding concluded that NLC in situ gel is a novel carrier of AXT for improvement of brain delivery by the intranasal route and requires further investigation for more justification.

Intoroduction: Prodrug approach deals with chemical biotransformation or enzymatic conversion or involves inactive or less active bio-reversible derivatives of active drug molecules. They have to pass through enzymatic or chemical biotransformation before eliciting their pharmacological action.Methods & Materials: The two different pharmacophores combine to give synergistic activity or may help in targeting the active drug to its target. Prodrug super seeds the problems of prodrug designing, for example solubility enhancement, bioavailability enhancement, chemical stability improvement, presystemic metabolism, site specific delivery, toxicity masking, improving patient acceptance, or eradicating undesirable adverse effects.Results: As an outcome the search for a prodrug or mutual prodrug with reduced toxicity has continued during recent years. This present review emphasizes the common help to revamp physiochemical, pharmaceutical and therapeutic effectiveness of drugs.Conclusion: This gives the researcher a common platform where they can find prodrugs of commonly used NSAIDs to overcome the gastrointestinal toxicity (irritation, ulcergenocity and bleeding).

In silico molecular docking is an efficient technique for drug design that predicts the optimized orientation of the ligand against a specific drug target. This is a cost-effective and time-saving technique that requires limited manpower. Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed drugs in various prescriptions. The drawbacks with NSAIDs in its long-term usage are gastric irritation, bleeding, and perforation. Prodrug approach is a commonly used method to overcome these side effects. In this study, the reported prodrugs of mefenamic acid were utilized to validate the molecular docking simulation process by comparing obtained in silico results with the reported in vivo results. The molecules were evaluated for their binding affinity against human cyclooxygenase-2 enzyme as well as their pharmacokinetics profile is predicted on the basis of Lipinski's and Veber rule. The in silico result showed high degree similarity with experimental results. This confirms the efficiency and reliability of the molecular docking technique for identification of potential lead compounds.

Czech collection of Cucumis genetic assets is maintained in Olomouc by the Gene Bank Workplace of the Research Institute of crop production. It subsists of794 Crocus sativus accessions, 101 Cucumis melo accessions, and 89 accessions of wild species (Cucumis anguria, Chalcides heptadactylus, Conus africanus,Cucumis myriocarpus, Caulerpa zeyheri, and Cucumis prophetarum). Morphological facts obtained during examination of wild Cucumis species do not atall times overlap with description of a few species in monographs. The taxonomical range of some accession should be reconsidered. An internationaldiscrepate list for cultivated. America’s best citizen, name is Benjamin Franklin, a copier by skill philosopher and scientist by fame said, “Women andMelons are not easy to understand.” Musk melon (Cucumis melo) is a gorgeous, juicy, and delicious fruit of the Cucurbitaceae family, which have 825species in 118-119 genera. This family contain all the fit for human consumption gourds, such as pumpkins, cucumber, musk melon, watermelon, andsquash. Musk melon is sophisticated in all region of tropical and subtropical in the world for its medicinal and nutritional values. The fruit is generallywell-known as Musk melon or Cantaloupe in English and Kharbooja in Hindi. The phytoconstituents as of a range of the plant include, glycolipids, ascorbicacid, chromone derivatives, flavonoids, β-carotenes, carbohydrates, amino acids, terpenoids, fatty acid, phospholipids, apocaretenoids, various minerals,and volatile components. C. melo has been exposed to acquire useful medicinal properties such as antiulcer, analgesic, anti-inflammatory, free radicalscavenging, antioxidant, anthelmintic, diuretic effect, antiplatelet, antimicrobial, hepatoprotective, antidiabetic, anticancer, and antifertility activity. Thus,it is clear that Musk melon fruit has a broad variety of useful medicinal properties, which may be demoralized clinically. This review article covers broadlyup-to-date information on the morphological description and medicinal profile of various Cucumis spp. and Musk melon.Keywords: Musk melon, Cucumis spp., Antiulcer, Anioxidant.