Living a healthy lifestyle is the most important need in the world today. However, oxidative stress (OS) is caused by several stress-inducing factors such as smoking, alcohol consumption, chronic diseases, and inflammatory responses, oxygen-free radicals are produced in excess and can damage major organs in the body. This phenomenon has been implicated in the pathogenesis of several gastrointestinal (GI) diseases, including gastritis, constipation, and inflammatory bowel diseases, which include Crohn’s disease, ulcerative colitis, functional dyspepsia, acid reflux, diverticular disease, and irritable bowel syndrome. In this review article, we provide a brief overview of the role of OS in the pathogenesis of GI disorders. Additionally, we discuss the therapeutic role of alkaline-reduced water (ARW) on GI diseases and existing studies on ARW related to GI diseases. Furthermore, we believe that findings from this review article will enhance the knowledge of the readers on the role of ARW on OS and inflammation-based GI diseases.

Study DesignA cross-sectional, case-control study.PurposeTo investigate associations between physical fitness measures and disabilities related to back pain and quality of life (QOL) by the presence of symptomatic lumbar spinal stenosis (LSS) in elderly Korean women.Overview of LiteratureLSS leads to decreased functioning and reduced QOL. However, correlations among physical fitness, disability, and QOL have not been investigated in elderly women with LSS.MethodsParticipants included women aged 65 years and older (n=192), divided into a study group (n=38) and a control group (n=154) based on the presence/absence of LSS. All participants underwent physical function and fitness tests. Oswestry disability index (ODI) scores and EuroQol five-dimensional questionnaire (EQ-5D-5L) scores were used to assess disability and health-related QOL.ResultsThe results for the handgrip strength, sit-and-reach, functional reach, and timed up and go (TUG) tests were significantly higher in the control group than the LSS group. ODI scores were significantly higher and EQ-5D-5L scores significantly lower in the LSS group. TUG and functional reach test scores were significantly correlated with ODI scores, and handgrip strength was strongly interrelated with ODI and EQ-5D-5L scores in the LSS group. No other physical fitness measures showed statistically significant relationships with ODI or EQ-5D-5L scores.ConclusionsIn elderly Korean women with LSS, back pain-related disability and QOL are significantly associated with some physical fitness parameters such as handgrip strength. Handgrip strength reflects general muscle strength, which is significantly interrelated with the level of disability and QOL. Our results suggest that enhancing generalized muscle strength helps to reduce disability due to back pain and improve QOL in patients with LSS.

The first aim of this study was to develop equations to predict physical activity energy expenditure (PAEE) for children utilizing heart rate monitors (HRM) and vector magnitudes (VM) from accelerometers. The second aim was to cross-validate the developed PAEE prediction equations and compare the equations to the pre-existing accelerometer-based PAEE equation (i.e., Trost). Seventy-five students in elementary school (from 10 to 13 years old) were classified into an equation calibration group (N = 50, 33 boys and 17 girls) and a cross-validation group (N = 25, 20 boys and 5 girls). Participants simultaneously wore a portable indirect calorimeter (Cosmed’s K4b²), a heart rate monitor on the chest, and an accelerometer on the right side of the waist. Then, the participants performed a series of various intensity activities. The energy expenditure (EE) measured by K4b² was set as the dependent variable. Multiple regression analysis was performed to derive the heart rate and accelerometer-based equations. The heart-rate-based EE equation had an explanatory power of adj. R² = 0.814 and the accelerometer-based EE equation had an explanatory power of adj. R² = 0.802. The VM-based EE indicated high mean absolute percent errors (MAPE) at light, moderate, and vigorous intensity. The heart-rate-based EE was included in the range of equivalence limit in all activities, but the VM and pre-existing equation showed some overestimation beyond the equivalence range. The agreement errors between the criterion EE and the estimated EE were lower in the heart-rate-based equation than the accelerometer-based equations (i.e., VM and Trost). The approach with the heart-rate-based EE equation demonstrated higher accuracy than the accelerometer-based EE equations. The results of the current study indicate that the heart-rate-based PAEE equation can be a potential method for estimating children’s PAEE.

Regular physical activity confers health benefits and improves the general quality of life. Recently, alkaline-reduced water (ARW) consumption has garnered increasing attention in the field of sports. ARW effectively inhibits the oxidative stress generated in cells during high-intensity exercises; however, whether it exerts similar effects during exhaustive exercises remains unknown. This study was designed as a randomized, controlled, crossover, double-blind clinical trial with a single intervention of ARW intake (pH 9.5, 10 mL/kg body weight) after intense exercise. The participants were divided into two groups, wherein they consumed either purified water (PW group) or ARW (ARW group). Blood samples were collected before exercise, immediately after exercise, and 15 min after drinking water. The serum levels of oxidative stress markers and fatigue markers were determined. The results showed that ROS (p < 0.01) and NO levels (p < 0.001) were significantly decreased after ARW intake, and the reduction was more pronounced than that in the PW group. Interestingly, the increase in GPx and MDA levels was mediated by ARW intake (both p < 0.05) after exercise. The levels of fatigue markers, such as lactate (p < 0.001), lactate dehydrogenase (p < 0.001), and phosphate (p < 0.001), were significantly reduced in both groups, with ARW intervention showing more decreased markers. The correlation analysis results showed that ARW may help maintain homeostatic conditions for ROS, antioxidant systems, and fatigue markers. These findings indicate that ARW consumption is effective in reducing oxidative stress and fatigue following exhaustive exercise and that ARW could be used as an antioxidant and anti-fatigue supplement after exhaustive physical exercise.

Background: The axial (horizontal) traction approach has been traditionally used for treatment of low back pain-related spinal disorders such as nuclear protrusion, primary posterolateral root pain, and lower thoracic disc herniation; however, it is known to have some technical limitations due to reductions of the spinal curve. Lumbar lordosis plays a pivotal function in maintaining sagittal balance. Recently, vertical traction and combination traction have been attracting attention due to improving therapeutic outcomes, although evidence of their clinical application is rare; therefore, this study was conducted to investigate the mechanical changes of lumbar intervertebral space, lordotic angle, and the central spinal canal area through vertical traction treatment using a spinal massage device in healthy participants. Methods: In total, 10 healthy subjects with no musculoskeletal disorders and no physical activity restrictions participated. The participants lay on the experimental device (CGM MB-1901) in supine extended posture and vertical traction force was applied in a posterior-to-anterior direction on the L3–4 and L4–5 lumbar sections at level 1 (baseline) and level 9 (traction mode). Magnetic resonance (MR) images were recorded directly under traction mode using the MRI scanner. The height values of the intervertebral space (anterior, center, and posterior parts) and lordosis angle of the L3–4 and L4–5 sections were measured using Image J software and the central spinal canal area (L4–5) was observed through superimposition method using the MR images. All measurement and image analyses were conducted by 2 experienced radiologists under a single-blinded method. Results: The average height values of the intervertebral space under traction mode were significantly increased in both L3–4 and L4–5 sections compared to baseline, particularly in the anterior and central parts but not in the posterior part. Cobb’s angle also showed significant increases in both L3–4 and L4–5 sections compared to baseline (p < 0.001). The central spinal canal area showed a slightly expanded feature in traction mode. Conclusions: In this pilot experiment, posterior-to-anterior vertical traction on L3–4 and L4–5 sections using a spinal massage device caused positive and significant changes based on increases of the intervertebral space height, lumbar lordosis angle, and central spinal canal area compared to the baseline condition. Our results are expected to be useful as underlying data for the clinical application of vertical traction.

PURPOSE: This study aimed to develop age- and sex-specific smoothed percentile curves for fitness items using LMS methods in Koreans aged 13–85 years or older.METHODS: A total of 559,430 individuals aged 13-85 years or older (adolescents: 13-18 years, adults: 19-64 years; older adults: >65 years) participated in the National Fitness Award (NFA) project in 2017, 2018, and 2019 in Korea. In this study, the results of body composition (body fat percent), muscle strength (absolute handgrip strength and relative handgrip strength), and flexibility (sit and reach) tests performed by adolescents, adults, and older adults, were analyzed. Cardiorespiratory fitness (20-m PACER, VO2max) was performed only by adolescents and adults. Percentile curves of fitness items smoothed by age- and sex-specific variables were calculated for fit using the LMS method.RESULTS: Percentile curves for each age- and sex-specific group were presented for each physical fitness component. Percent body fat in men and women increased from the age of 25 and 30 years, respectively. Flexibility showed a tendency to decrease sharply after the age of 65 and 70 years in men and women, respectively. Muscle strength decreased gradually after 40 years, and sharply after 60 years. Cardiorespiratory fitness tended to decrease from the age of 25 years in men and from 19 years in women.CONCLUSIONS: The NFA project dataset provided the opportunity to establish normative values for fitness items in Korean men and women aged 13-85 years or older. The use of the LMS method enabled factoring age in the analysis. Normative reference values of fitness items can be used to interpret individuals’ fitness levels during the everyday practice of fitness and/or in clinical settings.