Dr. Xiaojie Shi obtained his Ph.D. degree in Virology from Fudan University in 2014. He then joined the Lerner's Lab at SIAIS, ShanghaiTech University, as a postdoc involved in extending and developing the basic theories of the synthetic immune system under the mentorship of the late Richard A. Lerner; he worked there for several years. He expanded and developed the fundamental theories of synthetic immune systems, focusing on the construction and development of various combinatorial libraries with immense diversity, including antibodies, peptides, cytokines, transcription factors, and phenotypic selection systems, to re-establish a synthetic immune system that could mimic natural evolution in vitro. Since 2022, Shi has worked as a Research Associate at SIAIS, ShanghaiTech University. His research concentrates on utilizing synthetic immune systems in the study of innate immunity, autoimmunity, tumor immunity, and cell biology. He investigates the regulatory mechanisms underlying cell fate transitions, such as differentiation, transdifferentiation, and polarization in stem cells and somatic cells, and is dedicated to discovering new targets and innovative cell therapies for related diseases.