Micropollutants have become a serious environmental problem with several negative outcomes for human health and ecosystems. Many efforts have been made to remove micropollutants using a variety of physical, chemical and biological methods. By far, the most attention has been paid to microalgae-based technologies for wastewater treatment in order to obtain high-quality effluents, recover algal biomass for fertilizers, protein-rich feed, biofuel, and put them to other practical use. This paper reviews the potential of microalgae-based systems for the removal of organic micropollutants from open ponds to closed photobioreactors coupled by suspended microalgal cells, immobilized cells, or microalgae-microbial consortia. The inhibition of micropollutants on microalgae growth as well as micropollutant removal mechanisms performed by microalgae-based systems are also discussed. Other treatment methods for the removal of micropollutants are analyzed to show the advantages and limitations of microalgae-based treatment strategies, from which some possible combined systems can be suggested. Finally, some recommendations for future studies on this topic are proposed.