Lie symmetry analysis of differential equations provides a powerful and fundamental framework to the exploitation of systematic procedures leading to the integration by quadrature (or at least to lowering the order) of ordinary differential equations, to the determination of invariant solutions of initial and boundary value problems, to the derivation of conservation laws, to the construction of links between different differential equations that turn out to be equivalent. This paper reviews some well known results of Lie group analysis, as well as some recent contributions concerned with the transformation of differential equations to equivalent forms useful to investigate applied problems.