Acetonitrile is commonly used as an organic solvent and can also be used as an important intermediate in organic synthesis. Its widespread use has led to the development of new methods for the synthesis of a variety of important compounds. In the past decades, the conversion reactions of acetonitrile as a building block have become one of the most-attractive fields in organic synthesis. Especially in the field of electrochemical conversions involving acetonitrile, due to its good conductivity and environmentally friendly features, it has become a powerful and compelling tool to afford nitrogen-containing compounds or nitrile-containing compounds. In this review, we mainly discuss the research progress involving acetonitrile in the past five years, covering both conventional synthesis methods and electrochemical synthesis. Besides, a detailed discussion of the substrate scope and mechanistic pathways is provided.

A base-promoted amidation of 1-aryl-2,2,2-trifluoroethanones with aminesviaHaller–Bauer reaction has been developed. This reaction directly transforms aryl trifluoroethanone into amides without the use of stoichiometric chemical oxidants or transition-metal catalysts.

The long-distance transport of wastewater in sewers inevitably leads to the formation of biofilms on the inner wall of sewers. Numerous studies have focused on analyzing the hydrogen sulfide, methane production, and emission patterns associated with sewer biofilms in sewer systems. This study employed bibliometric methods to analyze the research progress in the field of sewer biofilms from 1995 to 2025, and revealed the associated development trend, international cooperation network, and research hotspots. The results demonstrate a substantial increase in the number of annual publications over the past decade, with China and Australia as the primary contributors. The journal Water Research has been found to exert a significant influence. The research hotspots concentrate on the generation and control of hydrogen sulfide and methane, sewer corrosion mechanisms, and microbial community dynamics, with chemical dosing, sulfate-reducing bacteria, and biofilm metabolism as the key directions. The evolution of keywords demonstrates that early research focused on organic matter transformation, and in recent years, there has been a shift towards microbial ecology and wastewater epidemiology, along with other emerging areas. Recent years have seen China as well as China’s institution and authors emerge as the primary contributors in the sewer biofilm field, a development attributable to the country’s policy support, which has precipitated the development of green technologies and smart monitoring systems. This study demonstrates the necessity of international cooperation and provides theoretical references and technological directions for future sewer biofilms research.