Liver injury caused by the irrational use of acetaminophen (APAP) represents a significant challenge in the field of public health. In clinical treatment, apart from N—acetylcysteine (NAC), the only approved antidote, there are extremely limited effective intervention measures for APAP-induced hepatotoxicity. Therefore, exploring novel liver-protecting drugs and elucidating their mechanisms of action is of great scientific significance and clinical value. Rosmarinic acid (RA), as a natural polyphenolic compound, has been proven to have significant antioxidant activity. Previous studies have shown that it has a protective effect against drug-induced liver injury. Nevertheless, the precise protective mechanism of RA in APAP-induced acute liver injury (AILI) has not been fully defined. This study was based on an AILI mouse model to systematically explore the liver-protecting effect of RA and its underlying molecular mechanisms. The research results showed that pretreatment with RA could notably mitigate liver pathological injury. It could decrease the activities of ALT and AST in the serum, suppress the liver inflammatory reaction, and reverse the decline in the levels of CAT, T-AOC, SOD, and GSH caused by APAP. Meanwhile, RA could enhance antioxidant defense capabilities by activating the Keap1/Nrf2/HO-1 signaling pathway, regulate the xCT/GPX4 axis to inhibit lipid peroxidation, and thus block the process of ferroptosis. In conclusion, this study confirmed that RA exerts a protective effect against AILI by regulating the Keap1/Nrf2/HO-1 axis to enhance antioxidant capacity and inhibit ferroptosis through the xCT/GPX4 pathway. Our research provides a theoretical basis for RA as a potential therapeutic agent for APAP-induced liver injury.

There is a wind interference effect between greenhouses in a group arrangement of solar greenhouse groups. To ensure the structural integrity of greenhouse groups situated in valleys, it becomes imperative to analyze both the wind pressure distribution patterns and the wind interference effects. This arises from the recognition that the wind load coefficients applicable to solar greenhouse groups nestled within valleys deviate from those observed in flat plains. The application of the contour modeling method facilitated a realistic reconstruction of the authentic topography within the study area. Subsequently, a wind field simulation was executed specifically for the constructed valley. The resultant wind field data for the studied valley area were then obtained. In the valley, nine solar greenhouses were systematically arranged in a three by three configuration. Special attention was directed towards assessing the surface wind pressures derived meticulously from the simulated wind field and wind direction angle of 0°. The findings elucidate the following: (a) The wind speed ratio exhibits a diminution on the leeward side of the mountain as compared to the windward side, with a notably reduced wind speed ratio observed in proximity to the mountain. (b) An amplification effect is discernible in the peripheral zone adjacent to the leading row of greenhouses, proximate to the incoming airflow. Particular emphasis is warranted regarding the reversal of wind direction observed in the secondary row of greenhouses positioned along the north wall and front roof, specifically at a wind angle of 0°, owing to the pronounced influence of interference effects. Hence, when undertaking the design and construction of a cluster of solar greenhouses within the valley terrain of Tibet, meticulous consideration must be directed towards both the meticulous calculation of wind loads within the periphery of the greenhouses and the judicious selection of the grouping’s location.

The wind pressure coefficient is essential for calculating the wind loads on greenhouses. The wind pressure on single-span arched greenhouses built in valleys differs from those in plain regions. To promote our understanding of wind characteristics and ensure the structural safety of greenhouses in valley areas, an analysis of the distribution law of wind pressure on greenhouses is required. Firstly, we carried out a survey on greenhouse distribution and undulate terrain distribution near greenhouses in Tibet and measured the air density in Lhasa, Tibet. Then, employing the validated realizable k-ε turbulence model and the verification of grid independence, the wind pressure on greenhouses with different greenhouse azimuths was investigated. According to the survey results, values, such as the distance between the greenhouse and the mountain in addition to the greenhouse azimuth, were also obtained for calculating the wind pressure on greenhouses placed in valleys. A calculation model considering the relationship between the mountain distance and the wind pressure coefficient is proposed, whose results fit well with the results from computational fluid dynamics. The relative errors between the two different results are within 15%. Research shows that there is a canyon wind effect in the valley area, and its effect on wind pressure should be considered in greenhouse design. This research is valuable for the design of plastic greenhouses built in Tibet or other valley regions.

In this paper, the effect of size on the wind pressure coefficient on the surface of solar greenhouses is investigated using numerical simulations. The models were designed with consistent ratios of ridge height to span and north wall height to ridge height across different spans. To effectively understand the impact of dimensions on wind pressure distribution, two wind directions—0° (north wind) and 180° (south wind)—which have previously been shown to impose significant overall wind loads on solar greenhouses, are focused on. It was found that the wind load per unit area increases continuously with greenhouse size. Wind-induced suction is particularly concentrated along the ridge, with greater suction on the leeward side compared to the windward side. The wind suction near the ridge is more significantly affected by greenhouse size. This study provides valuable insights for the practical engineering design of solar greenhouses.

Mortise and tenon joint is a common connection way of ancient Chinese timber structure. On this basis, in order to explore for a new type of mortise and tenon joint suitable for steel structure, the finite element model of a new type of steel mortise and tenon joint was established to simulate the whole behavior of it under tensile force and bending moment by using ABAQUS software. In this way, the effects of tenon number, tenon height and tenon width on the maximum local Mises stress, area of plastic stress region, tensile and flexural properties were discussed. The results show that the maximum local Mises stress, area of plastic stress region, tensile and flexural properties of the new steel mortise and tenon joint are significantly affected by the tenon number and height, while the tenon width has little effect on these properties. When the tenon number is 4, the tenon height is 15mm, and the tenon width is 5mm, the new steel mortise and tenon joint has the best mechanical performance, and the steel consumption is relatively lower.

Conventional structural analysis of multi-span glasshouses often idealises aluminium gutter–steel column connections as pinned or rigid, although their actual rotational restraint remains insufficiently quantified. In this study, 21 full-scale specimens were tested to investigate two representative configurations: STP joints between gutters and gable columns and STZ joints between gutters and intermediate columns. The measured secant rotational stiffness ranged from 108.5 to 185.5 kN·m/rad for STP joints and from 5.63 to 19.03 kN·m/rad for STZ joints. STP joints exhibited higher in-plane flexural resistance and rotational stiffness with smaller rotations, whereas STZ joints showed lower stiffness and greater nonlinear rotational deformation. The experimental results demonstrate that neither connection can be adequately represented as perfectly pinned or fully rigid. When the measured stiffnesses were introduced into an idealised elastic column model, the theoretical buckling capacity increased by 4.73–7.89% for STP end columns and 3.73–12.08% for STZ intermediate columns. The measured stiffnesses provide experimentally based rotational-spring parameters for refined glasshouse structural analysis.