Groundwater is the main source of drinking water supply in most urban environments around the world. The content of potentially toxic elements is increasing in many groundwater systems owing to inadequate groundwater recharge, aquifer overexploitation, natural source release, or various anthropogenic activities that lead to groundwater quality degradation. The ingestion of groundwater contaminated with potentially toxic elements has been reported to have harmful health effects. This study aimed to assess the presence of several potentially toxic elements (Al, As, B, Cr, Cu, Fe, Mn, and Zn) in groundwater of the Monterrey metropolitan area in Northern Mexico and the carcinogenic and noncarcinogenic human health risks associated with exposure. Multivariate statistics and geospatial analysis were applied to identify the causative determinants that modify the groundwater quality along the metropolitan area. Mean concentrations of trace metals remained below drinking water standards and World Health Organization guidelines. The risk of harmful effects on human health due to ingestion of all eight metal(loid)s in groundwater was assessed as 2.52 × 10⁻² for adults and 2.16 × 10⁻² for children, which can be considered as negligible chronic risk and a very low cancer risk. However, the risks of oral consumption of Cr being carcinogenic to children and adults were 7.9 × 10⁻³ and 9.2 × 10⁻⁴, respectively. As these values exceeded the target risk of 1 × 10⁻⁴, it can thus be considered “unacceptable”.