There has been an increasing interest in translating artificial intelligence (AI) research into clinically-validated applications to improve the performance, capacity, and efficacy of healthcare services. Despite substantial research worldwide, very few AI-based applications have successfully made it to clinics. Key barriers to the widespread adoption of clinically validated AI applications include non-standardized medical records, limited availability of curated datasets, and stringent legal/ethical requirements to preserve patients' privacy. Therefore, there is a pressing need to improvise new data-sharing methods in the age of AI that preserve patient privacy while developing AI-based healthcare applications. In the literature, significant attention has been devoted to developing privacy-preserving techniques and overcoming the issues hampering AI adoption in an actual clinical environment. To this end, this study summarizes the state-of-the-art approaches for preserving privacy in AI-based healthcare applications. Prominent privacy-preserving techniques such as Federated Learning and Hybrid Techniques are elaborated along with potential privacy attacks, security challenges, and future directions.

Recent years have witnessed widespread adoption of machine learning (ML)/deep learning (DL) techniques due to their superior performance for a variety of healthcare applications ranging from the prediction of cardiac arrest from one-dimensional heart signals to computer-aided diagnosis (CADx) using multi-dimensional medical images. Notwithstanding the impressive performance of ML/DL, there are still lingering doubts regarding the robustness of ML/DL in healthcare settings (which is traditionally considered quite challenging due to the myriad security and privacy issues involved), especially in light of recent results that have shown that ML/DL are vulnerable to adversarial attacks. In this paper, we present an overview of various application areas in healthcare that leverage such techniques from security and privacy point of view and present associated challenges. In addition, we present potential methods to ensure secure and privacy-preserving ML for healthcare applications. Finally, we provide insight into the current research challenges and promising directions for future research.

With the advent of machine learning (ML) and deep learning (DL) empowered applications for critical applications like healthcare, the questions about liability, trust, and interpretability of their outputs are raising. The black-box nature of various DL models is a roadblock to clinical utilization. Therefore, to gain the trust of clinicians and patients, we need to provide explanations about the decisions of models. With the promise of enhancing the trust and transparency of black-box models, researchers are in the phase of maturing the field of eXplainable ML (XML). In this paper, we provided a comprehensive review of explainable and interpretable ML techniques for various healthcare applications. Along with highlighting security, safety, and robustness challenges that hinder the trustworthiness of ML, we also discussed the ethical issues arising because of the use of ML/DL for healthcare. We also describe how explainable and trustworthy ML can resolve all these ethical problems. Finally, we elaborate on the limitations of existing approaches and highlight various open research problems that require further development.

With the advancement in artificial intelligence (AI) and machine learning (ML) techniques, researchers are striving towards employing these techniques for advancing clinical practice. One of the key objectives in healthcare is the early detection and prediction of disease to timely provide preventive interventions. This is especially the case for epilepsy, which is characterized by recurrent and unpredictable seizures. Patients can be relieved from the adverse consequences of epileptic seizures if it could somehow be predicted in advance. Despite decades of research, seizure prediction remains an unsolved problem. This is likely to remain at least partly because of the inadequate amount of data to resolve the problem. There have been exciting new developments in ML-based algorithms that have the potential to deliver a paradigm shift in the early and accurate prediction of epileptic seizures. Here we provide a comprehensive review of state-of-the-art ML techniques in early prediction of seizures using EEG signals. We will identify the gaps, challenges, and pitfalls in the current research and recommend future directions.

Despite significant improvements over the last few years, cloud-based healthcare applications continue to suffer from poor adoption due to their limitations in meeting stringent security, privacy, and quality of service requirements (such as low latency). The edge computing trend, along with techniques for distributed machine learning such as federated learning, has gained popularity as a viable solution in such settings. In this paper, we leverage the capabilities of edge computing in medicine by evaluating the potential of intelligent processing of clinical data at the edge. We utilized the emerging concept of clustered federated learning (CFL) for an automatic COVID-19 diagnosis. We evaluate the performance of the proposed framework under different experimental setups on two benchmark datasets. Promising results are obtained on both datasets resulting in comparable results against the central baseline where the specialized models (i.e., each on a specific image modality) are trained with central data, and improvements of 16% and 11% in overall F1-Scores have been achieved over the trained model trained (using multi-modal COVID-19 data) in the CFL setup on X-ray and Ultrasound datasets, respectively. We also discussed the associated challenges, technologies, and techniques available for deploying ML at the edge in such privacy and delay-sensitive applications.

Connected and autonomous vehicles (CAVs) will form the backbone of future next-generation intelligent transportation systems (ITS) providing travel comfort, road safety, along with a number of value-added services. Such a transformation—which will be fuelled by concomitant advances in technologies for machine learning (ML) and wireless communications—will enable a future vehicular ecosystem that is better featured and more efficient. However, there are lurking security problems related to the use of ML in such a critical setting where an incorrect ML decision may not only be a nuisance but can lead to loss of precious lives. In this paper, we present an in-depth overview of the various challenges associated with the application of ML in vehicular networks. In addition, we formulate the ML pipeline of CAVs and present various potential security issues associated with the adoption of ML methods. In particular, we focus on the perspective of adversarial ML attacks on CAVs and outline a solution to defend against adversarial attacks in multiple settings.