Nunzia Borrelli

Dr. Nunzia Borrelli

orcid

Research Focus & Metrics

Academic Career Length

8Years (2019-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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17 August 2019 in Journal of Clinical Medicine
Verified
Journal Article
Open access
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JSJolanda Sabatino
Jolanda Sabatino
Giovanni Di SalvoGiovanni Di Salvo
Giovanni Di Salvo
CPCostantina Prota
Costantina Prota
VBValentina Bucciarelli
Valentina Bucciarelli
MJManjit Josen
Manjit Josen
PDPiers E. F. Daubeney
Piers E. F. Daubeney
Background: Left ventricular (LV) diastolic dysfunction (DD) carries worse prognosis in childhood. 2-dimensional (2-D) left atrial (LA) strain accurately categorizes DD in adults but its role in children is unknown. Thus, the aim of this study is to investigate whether LA strain and strain rate could diagnose and classify DD in children with dilated (CMD), hypertrophic (HCM) and restrictive (RCM) cardiomyopathies (CM). Methods and Results: The study includes 136 children (aged 8.8 ± 6 years): 44 with DCM, 40 with HCM, 7 with RCM and 45 healthy controls (CTRL). They underwent standard echocardiographic examination and 2-D speckle-tracking analyses (LV longitudinal peak systolic strain (LS), LA peak systolic strain and strain rate). No significant differences in mitral E/A and pulmonary S/D ratios were observed among the four groups. Although E/E’ and indexed left atrial volumes were found to be significantly higher in HCM, DCM and RCM compared to CTRL (p < 0.001), they showed no significant difference among the three CM groups. LV LS values were significantly reduced in CM vs CTRL (p < 0.001) and in DCM vs HCM (p < 0.01), with no other differences between the remaining groups. LA peak systolic strain and strain rate values showed a steady and significant decrease with worsening of DD. Receiver Operating Characteristics (ROC) curves showed area under the curve of 0.976 (p < 0.001) for LA strain and 0.946 (p < 0.001) for LA strain rate, to distinguish CTRL from CMs. Conclusions: LA strain and strain rate could be a promising tool to better understand and classify DD in children with cardiomyopathies, opening the way to its clinical use.

NBNunzia Borrelli
Nunzia Borrelli
NGNicola Grimaldi
Nicola Grimaldi
GPGiovanni Papaccioli
Giovanni Papaccioli
FFFlavia Fusco
Flavia Fusco
MPMichela Palma
Michela Palma
Berardo SarubbiBerardo Sarubbi
Berardo Sarubbi
The number of adults with congenital heart disease (ACHD) has progressively increased in recent years to surpass that of children. This population growth has produced a new demand for health care. Moreover, the 2019 coronavirus pandemic has caused significant changes and has underlined the need for an overhaul of healthcare delivery. As a result, telemedicine has emerged as a new strategy to support a patient-based model of specialist care. In this review, we would like to highlight the background knowledge and offer an integrated care strategy for the longitudinal assistance of ACHD patients. In particular, the emphasis is on recognizing these patients as a special population with special requirements in order to deliver effective digital healthcare.

1 August 2019 in International Journal of Cardiology
Verified
Journal Article
Closed access
PTPaolo Trambaiolo
Paolo Trambaiolo
PBPietro BERTINI
Pietro BERTINI
NBNunzia Borrelli
Nunzia Borrelli
MPMarco Poli
Marco Poli
SRSilvio Romano
Silvio Romano
FGFabio Guarracino
Fabio Guarracino

30 November 2022 in Children
Verified
Journal Article
Open access
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SMSara Moscatelli
Sara Moscatelli
NBNunzia Borrelli
Nunzia Borrelli
JSJolanda Sabatino
Jolanda Sabatino
ILIsabella Leo
Isabella Leo
MAMartina Avesani
Martina Avesani
Giovanni Di SalvoGiovanni Di Salvo
Giovanni Di Salvo
Since its first description in 1971, the Fontan procedure and its modifications have led to a substantial improvement in the survival rates of patients with a variety of types of complex Congenital Heart Disease (CHD) characterised by the presence of a single, dominant ventricle. However, despite the significant improvement of the prognosis over the years, Fontan patients are still exposed to several cardiovascular and systemic complications. It is, therefore, important to fully understand the pitfalls hidden behind a Fontan anatomy and the potential predictors of ventricular failure. Cardiovascular imaging plays a key role in this context, allowing for the early identification of complications with important prognostic implications. Echocardiography remains the first-line imaging modality for serial evaluation of Fontan patients. However, there is a growing role of cardiovascular magnetic resonance and cardiac computed tomography from pre-operative assessment to longitudinal follow-up. The aim of this paper will be to provide a comprehensive overview of the role, strengths, and weaknesses of each imaging modality in the assessment of congenital cardiac conditions palliated with the Fontan procedure.

15 July 2021 in European Heart Journal Open
Verified
Journal Article
Open access
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NBNunzia Borrelli
Nunzia Borrelli
MBMargarita Brida
Margarita Brida
ACAaysha Cader
Aaysha Cader
JSJolanda Sabatino
Jolanda Sabatino
KCKatarzyna Czerwińska-Jelonkiewicz
Katarzyna Czerwińska-Jelonkiewicz
AGAlessia Gimelli
Alessia Gimelli
Women’s participation is steadily growing in medical schools, but they are still not sufficiently represented in cardiology, particularly in cardiology leadership positions. We present the contemporary distribution of women leaders in cardiology departments in the World Health Organization European region. Between August and December 2020, we applied purposive sampling to collect data and analyse gender distribution of heads of cardiology department in university/third level hospitals in 23 countries: Austria, Azerbaijan, Belgium, Bosnia-Herzegovina, Croatia, France, Germany, Greece, Italy, North Macedonia, Morocco, Poland, Portugal, Russia, Serbia, Slovakia, Slovenia, Spain, Switzerland, Tunisia, Turkey, Ukraine, and the UK. Age, cardiology subspecialty, and number of scientific publications were recorded for a subgroup of cardiology leaders for whom data were available. A total of 849 cardiology departments were analysed. Women leaders were only 30% (254/849) and were younger than their men counterpart (♀ 52.2 ± 7.7 years old vs. ♂ 58.1 ± 7.6 years old, P = 0.00001). Most women leaders were non-interventional experts (♀ 82% vs. ♂ 46%, P < 0.00001) and had significantly fewer scientific publications than men {♀ 16 [interquartile range (IQR) 2–41] publications vs. ♂ 44 (IQR 9–175) publications, P < 0.00001}. Across the World Health Organization European region, there is a significant gender disparity in cardiology leadership positions. Fostering a diverse and inclusive workplace is a priority to achieve the full potential and leverage the full talents of both women and men.

27 October 2023 in Children
Verified
Journal Article
Open access
PDF file
SMSara Moscatelli
Sara Moscatelli
VALERIA PERGOLAVALERIA PERGOLA
VALERIA PERGOLA
RMRaffaella Motta
Raffaella Motta
FFFederico Fortuni
Federico Fortuni
NBNunzia Borrelli
Nunzia Borrelli
Giovanni Di SalvoGiovanni Di Salvo
Giovanni Di Salvo
Tetralogy of Fallot (TOF) is the most common complex congenital heart disease with long-term survivors, demanding serial monitoring of the possible complications that can be encountered from the diagnosis to long-term follow-up. Cardiovascular imaging is key in the diagnosis and serial assessment of TOF patients, guiding patients’ management and providing prognostic information. Thorough knowledge of the pathophysiology and expected sequalae in TOF, as well as the advantages and limitations of different non-invasive imaging modalities that can be used for diagnosis and follow-up, is the key to ensuring optimal management of patients with TOF. The aim of this manuscript is to provide a comprehensive overview of the role of each modality and common protocols used in clinical practice in the assessment of TOF patients.