Stefano Granieri

Dr. Stefano Granieri

General Surgery Unit, ASST-Brianza, Vimercate Hospital, Via Santi Cosma e Damiano 10, 20871 Vimercate, Italy
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Research Focus & Metrics

Academic Career Length

8Years (2019-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 November 2021 in European Journal of Surgical Oncology
Verified
Journal Article
Closed access
SGStefano Granieri
Stefano Granieri
ABAlessandro M. Bonomi
Alessandro M. Bonomi
SFSimone Frassini
Simone Frassini
ACAndrea Piero Chierici
Andrea Piero Chierici
FBFederica Bruno
Federica Bruno
CCchristian cotsoglou
christian cotsoglou

19 December 2020 in Updates in Surgery
Verified
Journal Article
Open access
PDF file
ABAlessandro Michele Bonomi
Alessandro Michele Bonomi
SGStefano Granieri
Stefano Granieri
SGShailvi Gupta
Shailvi Gupta
MAMichele Altomare
Michele Altomare
SCStefano Piero Bernardo Cioffi
Stefano Piero Bernardo Cioffi
OCOsvaldo Chiara
Osvaldo Chiara
Despite its rarity, traumatic hollow viscus and mesenteric injury (HVMI) have high mortality and complication rates. There is no consensus regarding its best management. Our aim is to evaluate contrast enhanced CT (ceCT) in the screening of HVMI and its capability to assess the need for surgery. All trauma patients admitted to an urban Level 1 trauma center between 2010 and 2018 were retrospectively evaluated. Patients with ceCT scan prior to laparotomy were included. Patients requiring surgical repair of HVMI and a ceCT scan consistent with HVMI were considered true positives. Six ceCT scan criteria for HVMI were used; at least one criterion was considered positive for HVMI. Sensitivity (Sn), specificity (Sp), predictive values (PV), likelihood ratios (LR) and accuracy (Ac) of ceCT of single ceCT criteria and of the association of ceCT criteria were calculated using intraoperative findings as gold standard. Therapeutic time (TT), death probability (DP), and observed mortality (OM) were described. 114 of 4369 patients were selected for ceCT accuracy analysis; 47 were considered true positives. Sn of ceCT for HVMI was 97.9%, Sp 63.6%, PPV 66.2%, NPV 97.6%, + LR 2.69, −LR 0.03, Ac 78%; no single criterion stood out. The association of four or more criteria improved ceCT Sp to 98.5%, PPV to 95.6%, + LR to 30.5. Median TT was 2 h (IQR: 1–3 h). OM was 7.8%—not significantly higher than overall OM. CeCT in trauma has become a reliable screening test for HVMI and a valid exam to select HVMI patients for surgical exploration.

10 March 2020 in World Journal of Emergency Surgery
Verified
Journal Article
Open access
PDF file
SGStefano Granieri
Stefano Granieri
ERElisa Reitano
Elisa Reitano
FBFrancesca F. Bindi
Francesca F. Bindi
FRFederica F. Renzi
Federica F. Renzi
FSFabrizio Sammartano
Fabrizio Sammartano
OCOsvaldo Chiara
Osvaldo Chiara
Background: Motorcyclists are often victims of road traffic incidents. Though elderly patients seem to have worse survival outcomes and sustain more severe injuries than younger patients, concordance in the literature for this does not exist. The aim of the study is to evaluate the impact of age and injury severity on the mortality of patients undergoing motorcycle trauma. Methods: Data of 1725 patients consecutively admitted to our Trauma Center were selected from 2002 to 2016 and retrospectively analyzed. The sample was divided into three age groups: ≤ 17 years, 18–54 years, and ≥ 55 years. Mortality rates were analyzed for the overall population and patients with Injury Severity Score (ISS) ≥ 25. Differences in survival among age groups were evaluated with log-rank test, and multivariate logistic regression models were created to identify independent predictors of mortality. Results: A lower survival rate was detected in patients older than 55 years (83.6% vs 94.7%, p = 0.049) and in those sustaining critical injuries (ISS ≥ 25, 61% vs 83%, p = 0.021). Age (p = 0.027, OR 1.03), ISS (p < 0.001, OR 1.09), and Revised Trauma Score (RTS) (p < 0.001, OR 0.47) resulted as independent predictors of death. Multivariate analysis identified head (p < 0.001, OR 2.04), chest (p < 0.001, OR 1.54), abdominal (p < 0.001, OR 1.37), and pelvic (p = 0.014, OR 1.26) injuries as independent risk factors related to mortality as well. Compared to the theoretical probability of survival, patients of all age groups showed a survival advantage when managed at a level I trauma center. Conclusions: We detected anatomical injury distributions and mortality rates among three age groups. Patients aging more than 55 years had an increased risk of death, with a prevalence of severe chest injuries, while younger patients sustained more severe head trauma. Age represented an independent predictor of death. Management of these patients at a level I trauma center may lead to improved outcomes.

28 February 2023 in HPB
Verified
Journal Article
Closed access
SGStefano Granieri
Stefano Granieri
ABAlessandro Bonomi
Alessandro Bonomi
SFSimone Frassini
Simone Frassini
EGElson Gjoni
Elson Gjoni
AGAlessandro Germini
Alessandro Germini
CCchristian cotsoglou
christian cotsoglou

1 July 2021 in Critical Reviews in Oncology/Hematology
Verified
Journal Article
Closed access
SGStefano Granieri
Stefano Granieri
Michele AltomareMichele Altomare
Michele Altomare
FBFederica Bruno
Federica Bruno
SPSissi Paleino
Sissi Paleino
ABAlessandro M. Bonomi
Alessandro M. Bonomi
CCChristian Cotsoglou
Christian Cotsoglou

6 February 2020 in Journal of Trauma and Acute Care Surgery
Verified
Journal Article
Closed access
Simone FrassiniSimone Frassini
Simone Frassini
SGShailvi S. Gupta
Shailvi S. Gupta
SGStefano Granieri
Stefano Granieri
SCStefania S. Md Cimbanassi
Stefania S. Md Cimbanassi
FSFabrizio F. Sammartano
Fabrizio F. Sammartano
OCOsvaldo O. Md Chiara
Osvaldo O. Md Chiara
BACKGROUND: Hemodynamically unstable pelvic fractures often require a multi-modal approach including both operative and endovascular management. While an important adjunct in hemorrhage control, time to angioembolization even at the most advanced trauma centers may take hours. Extraperitoneal packing (EPP) is a fast and effective procedure that can immediately address pelvic hemorrhage from the retroperitoneal space in severe pelvic injuries. The aim of this study was to evaluate the efficacy of early EPP, looking at 24 hours and overall mortality, and the hemodynamic impact of EPP in unstable blunt pelvic trauma. METHODS: All trauma patients admitted to an urban Level I trauma center were evaluated from 2002 to 2018 in a retrospective single-center comparative study. Inclusion criteria were patients 14 years or older who sustained blunt trauma with pelvic fractures and hemodynamic instability. Exclusion criteria were a concomitant head injury (Abbreviated Injury Scale >3) and patients who underwent resuscitative thoracotomy. The patient population was divided into two groups: an EPP group and a no-EPP group. Propensity score matching was used to adjust for differences in baseline characteristics in the two groups: a one-to-one matched analysis using nearest-neighbor matching was performed based on the estimated propensity score of each patient. RESULTS: Two hundred forty-four patients presented hemodynamically unstable, with a pelvic fracture (180 no-EPP, 64 EPP). With propensity score matching, 37 patients in each group were analyzed. Survival within the first 24 hours was significantly improved in the EPP group (81.1% vs. 59.5%, p = 0.042) and we registered similar results in overall survival rate (78.4% EPP group vs. 56.8% no-EPP group, p = 0.047). Those patients who underwent early EPP (n = 64) were associated with a significant improvement in hemodynamic stability, with a pre-EPP mean arterial pressure of 49.9 mm Hg and post-EPP mean arterial pressure of 70.1 mm Hg (p < 0.01). CONCLUSION: Extraperitoneal pelvic packing is an effective procedure that can be performed immediately, even within the trauma bay, to improve hemodynamic stability and overall survival in patients who sustain severe blunt pelvic trauma. The early use of EPP can be lifesaving. LEVEL OF EVIDENCE: Therapeutic, Level III.