Background: This article presents the system architecture and validation of the NeuroSuitUp body–machine interface (BMI). The platform consists of wearable robotics jacket and gloves in combination with a serious game application for self-paced neurorehabilitation in spinal cord injury and chronic stroke. Methods: The wearable robotics implement a sensor layer, to approximate kinematic chain segment orientation, and an actuation layer. Sensors consist of commercial magnetic, angular rate and gravity (MARG), surface electromyography (sEMG), and flex sensors, while actuation is achieved through electrical muscle stimulation (EMS) and pneumatic actuators. On-board electronics connect to a Robot Operating System environment-based parser/controller and to a Unity-based live avatar representation game. BMI subsystems validation was performed using exercises through a Stereoscopic camera Computer Vision approach for the jacket and through multiple grip activities for the glove. Ten healthy subjects participated in system validation trials, performing three arm and three hand exercises (each 10 motor task trials) and completing user experience questionnaires. Results: Acceptable correlation was observed in 23/30 arm exercises performed with the jacket. No significant differences in glove sensor data during actuation state were observed. No difficulty to use, discomfort, or negative robotics perception were reported. Conclusions: Subsequent design improvements will implement additional absolute orientation sensors, MARG/EMG based biofeedback to the game, improved immersion through Augmented Reality and improvements towards system robustness.

This study aims to present the development of a wearable prototype device consisting of soft robotic gloves (SRGs), its integration into a wearable robotics platform for sensorimotor rehabilitation, and the device’s validation experiments with individuals suffering from impaired hand motor function due to neurological lesions. The SRG is tested and evaluated by users with spinal cord injury (SCI) and stroke. The proposed system combines multiple-sensor arrays with pneumatic actuation to assist finger movement during grasping tasks. Evaluations on SCI and stroke patients revealed that the gloves consistently improved finger and grip performance. Detailed analyses indicated observable differences in sensor-derived features during actuation versus non-actuation, with statistically significant modifications appearing in both time-domain and frequency-domain metrics. Although the stroke participants exhibited greater variability, all participants were able to use the system reporting low discomfort and effort. The findings underscore the potential for personalized calibration to further optimize therapeutic outcomes. In summary, the study validates the utility of these gloves as assistive and rehabilitative modalities, and future research will focus on refining the device in the context of multimodal wearable robotics and individualized neurorehabilitation strategies.

This study endeavored to design and develop an innovative closed-loop diagnostic and therapeutic system with the following objectives: (a) the noninvasive detection of glucose concentration in sweat utilizing nanonengineered screen-printed biosensors; (b) the management of measured data through a specialized computer system comprising both hardware and software components, thereby enabling the precise control of therapeutic responses via a patch-based nanomedicine delivery system. This initiative addresses the significant challenges inherent in the management of diabetes mellitus, including the imperative need for glucose-level monitoring to optimize glycemic control. Leveraging chronoamperometric results as a foundational dataset and the in vivo hypoglycemic activity of nanoemulsion formulations, this research underscores the efficacy and accuracy of glucose concentration estimation, decision-making mechanism responses, and transdermal hypoglycemic treatment effects, within the proposed system.

Intending to enable a broader collaboration with the scientific community while maintaining privacy of the data stored and generated in Living Labs, this paper presents the Shareable Data Publishing and Access Service for Living Labs, implemented within the framework of the H2020 VITALISE project. Building upon previous work, significant enhancements and improvements are presented in the architecture enabling Living Labs to securely publish collected data in an internal and isolated node for external use. External researchers can access a portal to discover and download shareable data versions (anonymised or synthetic data) derived from the data stored across different Living Labs that they can use to develop, test, and debug their processing scripts locally, adhering to legal and ethical data handling practices. Subsequently, they may request remote execution of the same algorithms against the real internal data in Living Lab nodes, comparing the outcomes with those obtained using shareable data. The paper details the architecture, data flows, technical details and validation of the service with real-world usage examples, demonstrating its efficacy in promoting data-driven research in digital health while preserving privacy. The presented service can be used as an intermediary between Living Labs and external researchers for secure data exchange and to accelerate research on data analytics paradigms in digital health, ensuring compliance with data protection laws.

In this manuscript, a methodology for analysing motor signals from Parkinson’s disease (PD) patients is presented. The signals are obtained from PD patients while wearing a glove device and sequentially performing standard motor tests. The signals are processed in order to detect the onset and offset from specific items (items 23-25) of the Unified Parkinson’s Disease Rating Scale (UPDRS) and then the isolated signal parts are analysed in order to quantity the motor findings defined in UPDRS for these items, such as hesitation, movement amplitude and frequency, and rotation range. The obtained results indicate that the methodology can achieve accurate motor assessment (related to ground-truth UPDRS) for both “Off” and “On” stages.

Currently, health tourists primarily rely on independent facilitators to manage and book their medical appointments and vacation plans. There is a notable absence of dedicated booking applications for health tourism packages. This paper proposes HealthTourismHub, an application designed to provide personalized packages that include medical appointments, accommodation options, and recommended tourism activities. It also serves as a platform for medical experts and accommodation providers, allowing health tourists to discover and connect with them, promoting local resources, and contributing to the sustainable growth of health tourism destinations. To incorporate personalization, HealthTourismHub uses an ontology that organizes medical and tourism data, along with a reasoner that generates new knowledge. This approach enables the application to offer customized packages and identify the most suitable providers for each user. Providers are strategically paired and located in close proximity, encouraging shorter travel distances and more efficient travel planning, with the package also including personalized tourism recommendations that benefit the local economy and contribute to a conscious tourism industry. A survey was conducted to assess the usability of the application and general perspectives towards health tourism, including motivations, concerns, and preferences. The results revealed an above-average SUS score, indicating that users found the application user-friendly and effective. Some areas for improvement were identified, such as error handling and additional functionalities. Nonetheless, HealthTourismHub shows great potential as a pioneer in the field of sustainable health tourism applications.