Four patients with extensive tinea infections caused by Trichophyton indotineae, resistant to terbinafine and partially responsive to itraconazole, were successfully treated with posaconazole after molecular identification confirmed T. indotineae. Given the growing terbinafine resistance associated with this pathogen, particularly in travellers from endemic areas, antifungal susceptibility testing is critical. Posaconazole, although not typically indicated for dermatophytoses, demonstrated complete resolution in these cases, highlighting its potential as an alternative treatment for resistant tinea infections.