This study aimed to compare the growth performance and economic profitability of rearing Oreochromis niloticus in floating cages using three feeding strategies (5 days a week, 6 days a week, and 7 days a week) coupled with three stocking densities (20, 40, and 60 fish·m⁻³). Male monosex fish measuring 6.44 ± 0.18 cm and weighing 3.42 ± 0.7 g were used. The controls were weighed every 15 days from the 35th day of rearing until 185 days to assess zootechnical parameters. BioMar feed (Efico Cromis 832F) was used during the study, and the feed ration was adjusted for each treatment every 2 weeks. At the end of the study, the average weights varied from 293.09 g to 468.41 g for the conditions of 40 fish·m⁻³ with a 5/7-day diet and 20 fish·m⁻³ with a 7/7-day diet, respectively. The yield per m² values were between 7.11 kg and 23.17 kg, respectively. On the other hand, the economic profitability was better with the condition of 40 fish.m⁻³ with daily feeding. These results suggest that in the Toho-Todougba lagoon complex, a stocking density between 40 and 60 fish·m⁻³ coupled with daily feeding (three times a day) promotes the optimization of fish production and profitability of fish farming.