The sCMOS imaging system with deep vacuum cooling technology has become a necessary way to improve the detection capability of space targets. In order to improve the detection capability of the photoelectric detection equipment for space targets, this paper developed the Highly Sensitive Deep Vacuum Cooling Imaging System (HSDVCIS). Firstly, we designed the imaging readout processing circuit using the GSENSE4040 sCMOS image sensor designed and manufactured by Gpixel and the deep vacuum cooling structure using thermoelectric cooling. Then, we tested the designed HSDVCIS with readout noise, dark current, and dynamic range of 3.96 $e^{-}$, 0.12 $e^{-}$/pixel/sec, and 84.49 dB, respectively, and tested the image sensor with a minimum cooling temperature of −40 °C. Finally, according to the results of observation experiments, we validated that the photoelectric detection equipment equipped with HSDVCIS improved the limiting detection magnitude (at SNR = 5 level) from 13.22 to 13.51 magnitudes within a 3 s exposure time by turning on the cooling function. Therefore, HSDVCIS designed in this paper can achieve highly sensitive detection of space targets. At the same time, the development of HSDVCIS also provides technical reserves and strong support for future research on the imaging systems using multiple image sensor mosaics.

High-resolution imaging with wide field of view (FoV) ground-based telescopes is often affected by skylight background and noise due to the detector, resulting in an inhomogeneous background. In this paper, we propose an improved method for spatial image non-uniformity correction based on partition processing. First, an evaluation metric is introduced to evaluate the partition size and automatically iterate a suitable partition value for different scenarios based on the different operating conditions of the telescope. Then, we iteratively calculate the mean and variance in each partitioned region to extract the background of each partitioned region. Finally, after applying bilinear interpolation to the background extracted from each region, the inhomogeneous background is obtained and removed from the original image. The experiments on the simulated and real images show that the proposed method can effectively remove the inhomogeneous background of spatial images and meet the requirements of the real-time processing of high-resolution images under long exposure conditions.