Recently, significant attention has been given to the effects of obesity-inducing neuroinflammation on the hypothalamus, particularly the activation of glial cells and neurodegenerative sequences. Understanding how high-fat diets provoke neuroinflammation is essential to propose preventative or management strategies combined with medication interventions such as liraglutide. Scientific studies related to obesity and high-fat diet (HFD) in adult humans and rodents and published in PubMed, Science

By 2050, the global population aged 60+ is expected to reach two billion. As the population ages, the prevalence of neurodegenerative disorders will increase, while depression and anxiety will continue to be major causes of disability. A diet rich in antioxidants can positively impact cognitive function and protect against psychological disorders. to summarize the evidence of the impact of the MIND diet in reducing risks or slowing neurodegenerative and psychological diseases. The data were collected by searching electronic databases, including PubMed and Science Direct, until September 2023. The search terms included 'Alzheimer's, Anxiety, Brain Health, Cognitive Decline, Dementia, Depression, Parkinson's, MIND diet, and psychological disorders.' Peer-reviewed studies conducted on individuals aged 18 or older were included. 135 papers were identified and reviewed. 26 full-text, relevant original articles were included. The study analyzed a sample of 37 to 16,058 participants, ages 20-97. Among the identified studies, 6 RCTs, 11 cross-sectional studies, and 9 longitudinal studies were analyzed. The results indicate that adherence to the MIND diet slows cognitive decline and positively influences cognitive function and verbal memory in later life, reducing the risk of developing Parkinsonism, non-motor symptoms, depressive symptoms, and lowering stress levels. Our systematic review implies that the MIND diet can enhance cognitive health and is highly beneficial for mitigating risks of dementia, physiological diseases, anxiety, and depression due to its superior antioxidant and anti-inflammatory activities. However, further research is required to evaluate its long-term effects on health.

Introduction and Objective: Obesity has increased worldwide, and existing anti-obesity medications have treatment limitations that diminish their overall benefits. This study aimed to investigate the effects of orlistat in combination with Elettaria cardamomum “Cardamom” (CAR) extract on working memory, recognition memory, anxiety, and inflammation within hippocampal tissue. Methods: Mice were categorized into two groups: a control group (CD) and a cafeteria diet (CAF) group induced with obesity (CAF) for 10 weeks. The groups were then subdivided into a CAF group treated with orlistat (CAF-ORL), a CAF group treated with orlistat and Elettaria cardamomum (CAF-ORL-CARD), and a group that continued on the CAF. The CAF-ORL group received orlistat at a dosage of 10 mg/kg/day for four weeks, while the CAF-ORL-CARD group received 10 mg/kg/day of orlistat and 500 mg/kg of CAR extract via oral gavage. In the 14th week, various assessments were conducted, including the novel object recognition (NOR) test, Y maze test, marble-burying test (MBT), open-field test, and TNF-α levels in the hippocampus. Result: TNF-α levels in the hippocampal tissue of the CAF group were elevated compared to the CD group (p < 0.01), whereas the CAF-ORL group exhibited reduced TNF-α levels compared to the CAF group (p < 0.01). Moreover, TNF-α levels in the CAF-ORL-CARD group were significantly lower than in the CAF-ORL group (p < 0.01). The recognition index was notably higher in the CAF-ORL group compared to the CAF group (p < 0.01) and higher in the CAF-ORL-CARD group compared to the CAF-ORL group (p < 0.01). However, there were no changes in the open-field test and Y maze test (p > 0.05). Conclusions: Orlistat combined with CAR has positive effects on neuroinflammation and memory, suggesting that this combination may offer potential therapeutic benefits for cognitive impairments and hippocampal dysfunction associated with obesity.

Background: Poor diet quality and fatigue adversely affect daily functioning and quality of life. Aim: The present study explored associations between dietary patterns, sleep quality, and fatigue, with a focus on potential associations with supplement use. Methods: A cross-sectional study recruited 400 adults (276 females). Data were collected via a face-to-face survey using validated Arabic questionnaires. Summary: 35.5% of participants were aged 18–24 years, and the overall mean BMI was 25.9 ± 4.54 kg/m ² . The average daily energy intake was 2057.5±563.9 kcal. Mean Food Group Diversity Score (FGDS) and Global Dietary Recommendations (GDR) scores were 3.25 ± 2.60 and 9.86 ± 2.25, respectively. Only 22.5% of participants reported taking vitamins and minerals. Supplement users had higher mean GDR scores than non-users (10.53 ± 2.38 vs. 9.66 ± 2.17). Overall, 40.9% of participants reported fairly good subjective sleep quality. Females reported a higher fatigue score than males (26.29 ± 19.17 vs. 16.96 ± 20.10, P < 0.001). FGDS was negatively associated with fatigue (β = −0.121, P = 0.028) among participants and positively associated with sleep quality score (β = 0.200, P = 0.009) among males. Also, GRD was positively and significantly associated with quality of life (β = 0.092, P = 0.031). Finally, poor sleep quality and fatigue were significant predictors of lower quality of life (β= −0.267, P < 0.001 vs. β = −0.427, P < 0.001). In conclusion, poor sleep quality and fatigue are highly prevalent among Jordanian adults, particularly women. Higher diet quality was associated with better sleep quality and quality of life, highlighting the potential role of dietary patterns as a modifiable lifestyle factor.

Background: Modern lifestyles characterized by artificial light exposure, screen use, and altered sleep routines may be related to eating behaviors and dietary patterns relevant to the gut microbial environment. Although these factors have been investigated individually, limited evidence has examined self-reported light-exposure behaviors, sleep, eating behavior, and gut microbiota-related dietary patterns simultaneously within a single analytical framework. Objective: The aim of this study was to examine associations between five self-reported light-exposure behaviors and the global PSQI score, eating-behavior domains, and FFQ-GM-derived gut microbiota-related dietary pattern scores among adults in the recruited sample. Methods: A cross-sectional study was conducted among 518 adults aged 18–64 years recruited in Amman, Jordan, between April and May 2026 using convenience sampling. Participants completed the LEBA, the Arabic PSQI, the Arabic TFEQ-R18, and an Arabic-adapted gut microbiota-focused food frequency questionnaire (FFQ-GM). Associations were examined using Spearman’s rho and multivariable linear regression; multiplicity across the 25 LEBA factor–outcome coefficient tests was addressed using the Benjamini–Hochberg false discovery rate. Results: In the analyzed sample, 87.3% of participants had a global PSQI score > 5. Several LEBA factor–outcome coefficients had nominal p values < 0.05. Blue-light-filter use was positively associated with the global PSQI score (β = 0.29, p = 0.020), whereas phone use in bed (β = −0.43, p = 0.002) and light exposure before bedtime (β = −0.51, p = 0.009) were negatively associated with the global PSQI score. After false-discovery-rate adjustment across the 25 individual coefficient tests, most individual associations did not remain below the 0.05 threshold; therefore, these coefficient-level findings are interpreted as exploratory. Conclusions: Self-reported light-exposure behaviors were associated with questionnaire-derived sleep scores, eating-behavior domains, and FFQ-GM-derived gut microbiota-related dietary pattern scores. The cross-sectional design does not establish temporal direction, causality, or biological mechanism.