To develop a simple rapid procedure for bioreduction of silver nanoparticles (AgNPs) using aqueous leaves extracts of Catharanthus roseus (C. roseus). Characterization were determined by using UV-Vis spectrophotometry, scanning electron microscopy (SEM), energy dispersive X-ray and X-ray diffraction. SEM showed the formation of silver nanoparticles with an average size of 67 nm to 48 nm. X-ray diffraction analysis showed that the particles were crystalline in nature with face centered cubic geometry. C. roseus demonstrates strong potential for synthesis of silver nanoparticles by rapid reduction of silver ions (Ag(+) to Ag(0)). This study provides evidence for developing large scale commercial production of value-added products for biomedical/nanotechnology-based industries.

Gastric cancer, a malignant and highly proliferative condition, has significantly affected a large population around the globe and is known to be caused by various factors including genetic, epigenetic, and environmental influences. Though the global trend of these cancers is declining, an increase in its frequency is still a threat because of changing lifestyles and dietary habits. However, genetic and epigenetic alterations related to gastric cancers also have an equivalent contribution towards carcinogenic development. DNA methylation is one of the major forms of epigenetic modification which plays a significant role in gastric carcinogenesis. Methylation leads to inactivation of some of the most important genes like DNA repair genes, cell cycle regulators, apoptotic genes, transcriptional regulators, and signalling pathway regulators; which subsequently cause uncontrolled proliferation of cells. Mutations in these genes can be used as suitable prognostic markers for early diagnosis of the disease, since late diagnosis of gastric cancers has a huge negative impact on overall patient survival. In this review, we focus on the important epigenetic mutations that contribute to the development of gastric cancer and the molecular pathogenesis underlying each of them. Methylation, acetylation, and histone modifications play an integral role in the onset of genomic instability, one of the many contributory factors to gastric cancer. This article also covers the constraints of incomplete knowledge of epigenetic factors influencing gastric cancer, thus throwing light on our understanding of the disease.

Shelterin Proteins and Cancer Shelterin proteins;telomeres;telomerase;tumorigenesis; The telomeric end structures of the DNA are known to contain tandem repeats of TTAGGG sequence bound with specialised protein complex called the

The essential oil extracted by hydro-distillation from rhizome of Curcuma caesia Roxb. grown in southern India were analyzed by gas chromatography and gas chromatography–mass spectrometry. A total of 35 volatile essential oil components were identified in the extracted oil of C. caesia representing tropolone (15.86 %) as major compound, ledol (3.27 %), β-elemenone (3.03 %) and α-bulnesene (3.02 %), spathulenol (2.42 %) as minor compounds and borneol (0.85 %), α-terpineol (0.77 %), eucalyptol (0.62 %), caryophyllene (0.45 %) as trace compounds. The results from our analysis indicated that levels of sesquiterpene (62.8 %) were more than those of monoterpene components (1.4 %).