James C Cusack, MD, FACS, is a graduate of Dartmouth College and Emory University Medical School who trained in surgery at Tufts-New England Medical Center. He completed a Research Fellowship at Brigham and Women’s Hospital and a Surgical Oncology Fellowship at MD Anderson Cancer Center. In 2000, he joined the staff at Massachusetts General Hospital (MGH), the faculty of Harvard Medical School, and the consulting staff at Dana-Farber Cancer Institute. He is Director of the Peritoneal Surface Malignancy Program and Surgical Director of the Young Adult Colorectal Cancer Program. He served on the Executive Council of the Society of Surgical Oncology (SSO) and was Chair of the SSO Scientific Program Committee. He also served on the American Society of Clinical Oncology (ASCO) Gastrointestinal Symposium Program Committee. Among Dr. Cusack’s numerous awards for his patient care are Boston Top Doctors, America’s Top Surgeons, America’s Top Doctors for Cancer, and Patients’ Choice Award. The Cusack Laboratory has made landmark contributions to the understanding of molecular mechanisms of chemotherapy resistance. Since 1995, Dr. Cusack’s research has been funded by NIH, American Cancer Society, biotechnology collaborators, and his grateful patients. Current research studies focus on the role of the microbiome on the development of early-onset colon cancer, molecular image-guided surgery, and defining the genetic characteristics of metastatic cancer relative to the primary cancer.