Accurate control of excavator trajectory is the foundation for the intelligent and unmanned development of excavators. The excavator operation process requires multiple actuators to cooperate to complete the response action. However, the existing control methods to realize a single actuator of the excavator can no longer meet the practical demand. Based on this, a hybrid adaptive quantum particle swarm optimization algorithm (HAQPSO) is proposed to tune the proportional integral derivative (PID) controller parameters for enhancing the trajectory control accuracy of excavator actuators. To increase particle randomization and search speed and avoid the local convergence of QPSO, the QPSO is combined with circle chaotic mapping, Gaussian mutation operators, and adaptive adjustment factors, while the linear transformation of the contraction-expansion coefficient (CE) is improved to the dynamic adjustment mode. Through the interface block, a co-simulation platform for the load-sensitive system excavator is constructed, and trajectory experiments of multiple actuator compound actions are carried out. The simulation results show that—compared with ZN-PID, PSO-PID, and QPSO-PID—the trajectory error accuracy of the boom is improved by 26.59%, 32.95%, and 9.44%, respectively, which proves the high control accuracy of HAQPSO-PID in controlling the trajectory of multiple actuators.