This study evaluated the anti-inflammatory effect of platelet-rich fibrin (PRF) applied to the extraction socket after impacted mandibular third molar surgery with subjective and objective parameters. Forty-eight patients with impacted wisdom teeth in bilateral and similar positions were included in the study. The control group was formed with the standard surgery and the PRF group was formed with local PRF application in addition to standard procedure (n = 96). The anti-inflammatory activity of PRF on postoperative 2nd and 7th days was evaluated subjectively by clinical parameters and objectively by biochemical parameters. Postoperative 2nd- and 7th-day follow-up data of pain, edema, and trismus in the PRF group were found to be statistically significantly lower. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were found to be statistically significantly lower in the PRF group than the control in the postoperative 2nd-day follow-up period (p < 0.001). There was no statistically significant difference in interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-α) parameters when the PRF group and the control group were compared in both follow-up periods (p > 0.05). The study has demonstrated the effectiveness of locally applied PRF after ITM surgery via clinical parameters and objective data. The quantitative analysis of CRP and ERS can be an effective parameter in determining the amount of inflammation after ITM surgery.

Baştuğ AY, et al. J Periodontal Implant Sci. 2021 Dec;52:e2. https://doi.org/10.5051/jpis.2101360068

Background and Objectives: In this experimental study, the prophylactic effect of systemically administered erythropoietin (EPO) in medication-related osteonecrosis of the jaw (MRONJ) was evaluated. Materials and Methods: The osteonecrosis model was established using 36 Sprague Dawley rats. EPO was systemically applied before and/or after tooth extraction. Groups were formed based on the application time. All samples were evaluated histologically, histomorphometrically, and immunohistochemically. A statistically significant difference in new bone formation was observed between the groups (p < 0.001). Results: When new bone-formation rates were compared, no significant differences were observed between the control group and the EPO, ZA+PostEPO, and ZA+Pre-PostEPO groups (p = 1, 0.402, and 1, respectively); however, this rate was significantly lower in the ZA+PreEPO group (p = 0.021). No significant differences in new bone formation were observed between the ZA+PostEPO and ZA+PreEPO groups (p = 1); however, this rate was significantly higher in the ZA+Pre-PostEPO group (p = 0.009). The ZA+Pre-PostEPO group demonstrated significantly higher intensity level in VEGF protein expression than the other groups (p < 0.001). Conclusions: Administering EPO two weeks pre-extraction and continuing EPO treatment for three weeks post-extraction in ZA-treated rats optimized the inflammatory reaction, increased angiogenesis by inducing VEGF, and positively affected bone healing. Further studies are needed to determine the exact durations and doses.

Botulinum Toksinin Komplikasyon ve Yan Etkileri Nuray YILMAZ ALTINTAŞ Dişsiz Çenelerin Rehabilitasyonunda All-On-4İmplant Tedavi Konsepti Ümmügülsüm COŞKUN Güncel Vertikal ve Horizontal Ögmentasyon TekniklerindenKhoury ve Urban Tekniği Turan ÖZTÜRK Kevser SANCAK İmplant Stabilite Ölçüm Yöntemleri Gökhan GÜRSES Odontojenik Kist ve Tümörler Sefa ÇOLAK Oral Potansiyel Malign Bozuklukların Klinik Özellikleri Eda İZGİ Ortognatik Cerrahide Mandibuler Osteotomiler Mustafa Sami DEMİRSOY Periapikal Cerrahi Yunus BALEL Peri-İmplantitis Tedavisinde Güncel Yaklaşımlar Başak BIYIKOĞLU Temporomandibular Eklem Osteoartritinde İnterdisipliner Yaklaşım Gonca DUYGU Temporomandibular Eklem RahatsızlıklarındaKonservatif Tedavi Yaklaşımları Özlem GERGİNOK KAYA Mehmet Emin TOPRAK