Impacts caused by cancer and associated treatment may change with time. The objective of this study is to examine the change trajectory of symptom distress, coping strategies, and spiritual wellbeing in colorectal cancer patients during chemotherapy and to further examine the predictors of spiritual wellbeing. A prospective longitudinal repeated measures study design was employed. A total of 97 patients undergoing chemotherapy for the first time were enrolled. A structured questionnaire was used to collect data at three timepoints, which were before chemotherapy (T0), during chemotherapy (T1: 3 months after T0), and after chemotherapy (T2: 6 months after T0). The results of this study show that patients have significantly lower spiritual wellbeing and significantly higher symptom distress during chemotherapy treatment (T1). Family support (B = 0.39, p = 0.007) and problem-focused coping strategies (B = 0.47, p = 0.001) are significant predictors of spiritual wellbeing before chemotherapy (T0). Symptom distress (B = −0.18, p = 0.048) and problem-focused coping strategies (B = 0.26, p = 0.028) are significant predictors of spiritual wellbeing during chemotherapy (T1). The results provide care recommendations for different stages of chemotherapy to help to achieve more precise patient care and improve care quality.

Background: The ever-changing health care landscape and emerging disease threats in recent years have significantly strained the global health care system. Nurse practitioners (NPs) face greater challenges at work today than ever. However, over time, poor working conditions affect NPs' coping mechanisms, organizational cohesion, and ability to maintain control over their professional and personal lives. Purpose: To explore the relationships between organizational commitment, coping, and resilience among Taiwanese NPs and assess the mediating role of coping. Methodology: Cross-sectional design, convenience sampling. We conducted an online questionnaire survey and recruited 610 Taiwanese NPs. The survey featured questions about organizational commitment, coping, and resilience. Results: Taiwanese NPs exhibited moderate to high resilience and organizational commitment levels. The most commonly reported coping strategy was emotional adjustment. Organizational commitment and coping were found to be important predictors of resilience. The overall regression prediction model exhibits 28% exploratory power. The final mediation model confirms that coping, directly and indirectly, influenced resilience while partially mediating the influence of organizational commitment on resilience. Conclusions: Taiwanese NPs should cultivate awareness of positive behaviors and emotion-focused coping strategies. Strengthening coping abilities and organizational commitment can enhance their resilience in recovering from major incidents. Implications: To reduce the lasting psychological impact of unexpected workplace stressors on NPs, hospital administrators should prioritize their awareness and utilization of positive and negative coping strategies. Developing a supportive working environment based on organizational cohesion, reinforcing positive coping behaviors, and enhancing resilience can further strengthen their ability to recover from adversity.