Ioannis Manolitsis

Dr. Ioannis Manolitsis

orcid

Research Focus & Metrics

Academic Career Length

6Years (2021-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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26 May 2022 in World Journal of Urology
Verified
Journal Article
Closed access
PDF file
LTLazaros Tzelves
Lazaros Tzelves
LLLazaros Lazarou
Lazaros Lazarou
GEORGIOS FERETZAKISGEORGIOS FERETZAKIS
GEORGIOS FERETZAKIS
Dimitris KallesDimitris Kalles
Dimitris Kalles
PMPANAGIOTIS MOURMOURIS
PANAGIOTIS MOURMOURIS
IVIoannis Varkarakis
Ioannis Varkarakis

4 May 2024 in Cancers
Verified
Journal Article
Open access
PDF file
TBThemistoklis Bellos
Themistoklis Bellos
IMIoannis Manolitsis
Ioannis Manolitsis
SKStamatios Katsimperis
Stamatios Katsimperis
PJPatrick Juliebø-Jones
Patrick Juliebø-Jones
GEORGIOS FERETZAKISGEORGIOS FERETZAKIS
GEORGIOS FERETZAKIS
LTLazaros Tzelves
Lazaros Tzelves
With the rapid increase in computer processing capacity over the past two decades, machine learning techniques have been applied in many sectors of daily life. Machine learning in therapeutic settings is also gaining popularity. We analysed current studies on machine learning in robotic urologic surgery. We searched PubMed/Medline and Google Scholar up to December 2023. Search terms included “urologic surgery”, “artificial intelligence”, “machine learning”, “neural network”, “automation”, and “robotic surgery”. Automatic preoperative imaging, intraoperative anatomy matching, and bleeding prediction has been a major focus. Early artificial intelligence (AI) therapeutic outcomes are promising. Robot-assisted surgery provides precise telemetry data and a cutting-edge viewing console to analyse and improve AI integration in surgery. Machine learning enhances surgical skill feedback, procedure effectiveness, surgical guidance, and postoperative prediction. Tension-sensors on robotic arms and augmented reality can improve surgery. This provides real-time organ motion monitoring, improving precision and accuracy. As datasets develop and electronic health records are used more and more, these technologies will become more effective and useful. AI in robotic surgery is intended to improve surgical training and experience. Both seek precision to improve surgical care. AI in ‘’master–slave’’ robotic surgery offers the detailed, step-by-step examination of autonomous robotic treatments.

21 April 2022 in PLOS ONE
Verified
Journal Article
Open access
PDF file
LTLazaros Tzelves
Lazaros Tzelves
IMIoannis Manolitsis
Ioannis Manolitsis
IVIoannis Varkarakis
Ioannis Varkarakis
Mirjana IvanovićMirjana Ivanović
Mirjana Ivanović
MKMiltiadis Kokkonidis
Miltiadis Kokkonidis
AVAntonis Valachis
Antonis Valachis
Introduction: Breast and prostate cancer survivors can experience impaired quality of life (QoL) in several QoL domains. The current strategy to support cancer survivors with impaired QoL is suboptimal, leading to unmet patient needs. ASCAPE aims to provide personalized- and artificial intelligence (AI)-based predictions for QoL issues in breast- and prostate cancer patients as well as to suggest potential interventions to their physicians to offer a more modern and holistic approach on cancer rehabilitation. Methods and analyses: An AI-based platform aiming to predict QoL issues and suggest appropriate interventions to clinicians will be built based on patient data gathered through medical records, questionnaires, apps, and wearables. This platform will be prospectively evaluated through a longitudinal study where breast and prostate cancer survivors from four different study sites across the Europe will be enrolled. The evaluation of the AI-based follow-up strategy through the ASCAPE platform will be based on patients’ experience, engagement, and potential improvement in QoL during the study as well as on clinicians’ view on how ASCAPE platform impacts their clinical practice and doctor-patient relationship, and their experience in using the platform. Ethics and dissemination: ASCAPE is the first research project that will prospectively investigate an AI-based approach for an individualized follow-up strategy for patients with breast- or prostate cancer focusing on patients’ QoL issues. ASCAPE represents a paradigm shift both in terms of a more individualized approach for follow-up based on QoL issues, which is an unmet need for cancer survivors, and in terms of how to use Big Data in cancer care through democratizing the knowledge and the access to AI and Big Data related innovations. Trial registration: Trial Registration on clinicaltrials.gov: NCT04879563.

29 June 2023
Verified
Book Chapter
Open access
PDF file
IMIoannis Manolitsis
Ioannis Manolitsis
GFGeorgios Feretzakis
Georgios Feretzakis
LTLazaros Tzelves
Lazaros Tzelves
DKDimitris Kalles
Dimitris Kalles
SKStamatis Katsimperis
Stamatis Katsimperis
IVIoannis Varkarakis
Ioannis Varkarakis
Artificial Intelligence (AI) has shown the ability to enhance the accuracy and efficiency of physicians. ChatGPT is an AI chatbot that can interact with humans through text, over the internet. It is trained with machine learning algorithms, using large datasets. In this study, we compare the performance of using a ChatGPT API 3.5 Turbo model to a general model, in assisting urologists in obtaining accurate, valid medical information. The API was accessed through a Python script that was applied specifically for this study based on 2023 EAU guidelines in PDF format. This custom-trained model leads to providing doctors with more precise, prompt answers about specific urologic subjects, thus helping them, ultimately, providing better patient care.

Verified
Journal Article
Open access
PDF file
PMPANAGIOTIS MOURMOURIS
PANAGIOTIS MOURMOURIS
LTLazaros Tzelves
Lazaros Tzelves
GEORGIOS FERETZAKISGEORGIOS FERETZAKIS
GEORGIOS FERETZAKIS
Dimitris KallesDimitris Kalles
Dimitris Kalles
IMIoannis Manolitsis
Ioannis Manolitsis
ASAndreas Skolarikos
Andreas Skolarikos
Objectives: Artificial intelligence (AI) is increasingly used in medicine, but data on benign prostatic enlargement (BPE) management are lacking. This study aims to test the performance of several machine learning algorithms, in predicting clinical outcomes during BPE surgical management. Methods: Clinical data were extracted from a prospectively collected database for 153 men with BPE, treated with transurethral resection (monopolar or bipolar) or vaporization of the prostate. Due to small sample size, we applied a method for increasing our dataset, Synthetic Minority Oversampling Technique (SMOTE). The new dataset created with SMOTE has been expanded by 453 synthetic instances, in addition to the original 153. The WEKA Data Mining Software was used for constructing predictive models, while several appropriate statistical measures, like Correlation coefficient (R), Mean Absolute Error (MAE), Root Mean-Squared Error (RMSE), were calculated with several supervised regression algorithms - techniques (Linear Regression, Multilayer Perceptron, SMOreg, k-Nearest Neighbors, Bagging, M5Rules, M5P - Pruned Model Tree, and Random forest). Results: The baseline characteristics of patients were extracted, with age, prostate volume, method of operation, baseline Qmax and baseline IPSS being used as independent variables. Using the Random Forest algorithm resulted in values of R, MAE, RMSE that indicate the ability of these models to better predict % Qmax increase. The Random Forest model also demonstrated the best results in R, MAE, RMSE for predicting % IPSS reduction.Conclusions: Machine Learning techniques can be used for making predictions regarding clinical outcomes of surgical BPRE management. Wider-scale validation studies are necessary to strengthen our results in choosing the best model.

28 April 2023 in Journal of Clinical Medicine
Verified
Journal Article
Open access
PDF file
IMIoannis Manolitsis
Ioannis Manolitsis
GEORGIOS FERETZAKISGEORGIOS FERETZAKIS
GEORGIOS FERETZAKIS
SKStamatios Katsimperis
Stamatios Katsimperis
PAPanagiotis Angelopoulos
Panagiotis Angelopoulos
ELEvangelos Loupelis
Evangelos Loupelis
ASAndreas Skolarikos
Andreas Skolarikos
Purpose: The high incidence of urinary tract infections (UTIs), often in nosocomial environments, is a major cause of antimicrobial resistance (AMR). The dissemination of antibiotic-resistant infections results in very high health and economic burdens for patients and healthcare systems, respectively. This study aims to determine and present the antibiotic resistance profiles of the most common pathogens in a urology department in Greece. Methods: During the period 2019–2020, we included 12,215 clinical samples of blood and urine specimens that tested positive for the following pathogens: Escherichia coli, Enterococcus faecium, Enterococcus faecalis, Proteus mirabilis, Klebsiella pneumoniae, or Pseudomonas aeruginosa, as these are the most commonly encountered microbes in a urology department. Results: The analysis revealed a 22.30% mean resistance rate of E. coli strains with a 76.42% resistance to ampicillin and a 54.76% resistance rate to ciprofloxacin in the two-year period. It also showed an approximately 19% resistance rate of P. mirabilis strains and a mean resistance rate of 46.205% of K. pneumoniae strains, with a decreasing trend during the four semesters (p-value < 0.001), which presented an 80% resistance rate to ampicillin/sulbactam and 73.33% to ciprofloxacin. The resistance to carbapenems was reported to be 39.82%. The analysis revealed a 24.17% mean resistance rate of P. aeruginosa with a declining rate over the two-year period (p-value < 0.001). The P. aeruginosa strains were 38% resistant to fluoroquinolones and presented varying resistance against carbapenems (31.58% against doripenem and 19.79% against meropenem). Regarding the Enteroccocal strains, a 46.91% mean resistance was noted for E. faecium with 100% resistance to ampicillin, and a 24.247% mean resistance rate for E. faecalis strains that were 41% resistant to ciprofloxacin. Both types showed 100% sensitivity to linezolid. Conclusions: The dissemination of antibiotic-resistant pathogens poses the need to implement surveillance programs and, consequently, to develop strategies to prevent the emergence of such pathogens in order to optimize patient outcomes.