The aim of this study was to evaluate the biocompatibility of the regeneration of the dentin–pulp complex in a murine model with different treatments with MTA Angelus, NeoMTA, and TheraCal PT. An in vivo controlled experimental study of 15 male Wistar rats forming three study groups, the upper and lower central incisors were selected where pulpotomies were conducted, leaving a central incisor as control at 15, 30, and 45 days. For data analysis, these were expressed as mean ± standard deviation and were examined by Kruskal–Wallis test. Three factors were analyzed as follows: “inflammatory infiltrate; disorganization of pulp tissue, and the formation of reparative dentin”. No statistical significance was found between the different groups (p > 0.05). Treatment with these three biomaterials (MTA, TheraCal PT, and Neo MTA) presented an inflammatory infiltrate and slight disorganization of the odontoblast layer in the pulp tissue of a murine model, with normal coronary pulp tissue and the formation of reparative dentin in the three experimental groups. Thus, we are able to conclude that all three are biocompatible materials.

Orti V, et al. J Periodontal Implant Sci. 2016 Oct;46(5):291-302. https://doi.org/10.5051/jpis.2016.46.5.291

The objective of this article was to carry out a systematic review of the literature to determine the different therapeutic uses of chitosan-based hydrogels and their uses in dental therapy, as well as the modification and improvement of dental materials to promote research related to chitosan and its incorporation into dentistry as an adjunct or replacement in some dental treatments. Chitosan is a natural polymer obtained from the deacetylation of chitin, a polysaccharide abundant in nature, which, due to its biocompatibility, high biodegradability, non-antigenicity, and its ease of acquisition, has attracted biomedical interest, including in dentistry. Recent studies have shown that chitosan can be integrated into dental materials to obtain remineralizing effects, such as for antimicrobial agents, osteogenic agents, and pulp regeneration treatment. A bibliographic search was carried out in PubMed from 2018 to 2023. The results showed a wide range of uses for chitosan in the dental field, particularly its use as a remineralizing agent for tooth enamel; It has also been used in tissue regeneration mainly because of its osteogenic activity, as an antimicrobial agent, and as a vehicle for the application of medications. The use of chitosan as a nanobiomaterial is an interesting topic, since chitosan shows potential for new dental materials, either as an active ingredient or as an adjuvant vehicle for other materials.

Pandemia debido a que, como profesionales

The aim of this study was to determine the effect of propolis on non-surgical periodontal therapy in patients with chronic periodontitis (CP) as it appears in the recent literature. Propolis is a natural and biocompatible resinous substance that has shown, by means of several scientific studies, to possess medicinal properties such as antimicrobial, healing, anesthetic, anti-inflammatory, and analgesic, among others. There are several studies that have reported the use of propolis as a non-surgical treatment of CP, its comparison with other antimicrobials, and the improvement of clinical and microbiological parameters with scaling and root planing (SRP). A bibliographic search was conducted in the PubMed, Google Scholar, Web of Science, and Science Direct databases up to 2021. The results showed that there are very few reports focused on clinical studies; however, according to the analyzed data, propolis could be a good adjuvant for the treatment of patients with chronic periodontitis compared to the conventional treatment (SRP).

One of the main disadvantages of cements based on Ca(OH)₂/iodoform is the potential risk of intracanal absorption. Polydimethylsiloxane-based cement have been shown to be less cytotoxic and have better intracanal flow and viscosity as well as being less cytotoxic than epoxy resin-based cement. Titanium diisopropoxide bis (acetylacetonate) (Tyzor AA) is a catalyst that due to its properties could improve the handling of polydemethylsiloxane without affecting its sealing properties. In the present study, we evaluated the cytotoxicity and biocompatibility of a new hydrophobic endodontic sealant based on polydimethylsiloxane-Tyzor AA as a catalyst. A study was carried out in human fibroblasts performing an MTT assay to evaluate cell viability and an in vivo rat model for its biocompatibility at 15 and 30 days. The data and the histological evaluation were analyzed using a Cochran Q test with a value of p < 0.05. Two freshly mixed formulations showed (86.82%) and formulation V4 (24 h) set showed cell viability (86.98%). The in vivo test of formulation V1 (30 days) showed a value of 0.416 in Cochran's Q test. Therefore, it is concluded that the new sealant showed acceptable biocompatibility according to international standards. Graphical Abstract