Numerous factors can contribute to the development of neurodegenerative disorders (NDs), such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Huntington’s disease, and multiple sclerosis. Oxidative stress (OS), a fairly common ND symptom, can be caused by more reactive oxygen species being made. In addition, the pathological state of NDs, which includes a high number of protein aggregates, could make chronic inflammation worse by activating microglia. Carotenoids, often known as “CTs”, are pigments that exist naturally and play a vital role in the prevention of several brain illnesses. CTs are organic pigments with major significance in ND prevention. More than 600 CTs have been discovered in nature, and they may be found in a wide variety of creatures. Different forms of CTs are responsible for the red, yellow, and orange pigments seen in many animals and plants. Because of their unique structure, CTs exhibit a wide range of bioactive effects, such as anti-inflammatory and antioxidant effects. The preventive effects of CTs have led researchers to find a strong correlation between CT levels in the body and the avoidance and treatment of several ailments, including NDs. To further understand the connection between OS, neuroinflammation, and NDs, a literature review has been compiled. In addition, we have focused on the anti-inflammatory and antioxidant properties of CTs for the treatment and management of NDs.

Nanocomposite polymeric gels infused with fluorescent nanoparticles have surfaced as a propitious category of substances for biomedical purposes owing to their exceptional characteristics. The aforementioned materials possess a blend of desirable characteristics, including biocompatibility, biodegradability, drug encapsulation, controlled release capabilities, and optical properties that are conducive to imaging and tracking. This paper presents a comprehensive analysis of the synthesis and characterization of fluorescent-nanoparticle-impregnated nanocomposite polymeric gels, as well as their biomedical applications, such as drug delivery, imaging, and tissue engineering. In this discourse, we deliberate upon the merits and obstacles linked to these substances, encompassing biocompatibility, drug encapsulation, optical characteristics, and scalability. The present study aims to provide an overall evaluation of the potential of fluorescent-nanoparticle-impregnated nanocomposite polymeric gels for biomedical applications. Additionally, emerging trends and future directions for research in this area are highlighted.

Introduction: Argemone mexicana, commonly known as the Mexican poppy, has earned significant recognition in the traditional healing systems of the Eastern Indian region, where it has been used for centuries as a folk remedy for a variety of diseases. The study was based on search or identified through Pubmed, Google Scholar, Science Direct, etc. Meta-analysis: Phytochemical analysis has demonstrated that the alkaloids present in A. mexicana exhibit potent antimicrobial properties, making the plant an effective natural remedy for treating infections caused by bacteria, fungi, and viruses. In addition, the plant’s flavonoids and phenolic compounds are recognized for their strong anti-inflammatory and antioxidant activities, which play a crucial role in alleviating pain, reducing inflammation, and promoting tissue repair. Furthermore, A. mexicana has shown significant analgesic effects, which support its traditional use as a pain reliever. The integration of ethnobotanical knowledge with modern pharmacological research is essential for fully unlocking the therapeutic potential of A. mexicana. Future Scope: Future studies must focus on comprehensive clinical trials, toxicological evaluations, and in-depth mechanistic investigations to validate the efficacy and safety of A. mexicana in human populations. Conclusion: This review highlights the urgent need for further research to bridge the gap between traditional knowledge and contemporary scientific understanding. By advancing the study of A. mexicana, there is a significant opportunity to develop novel, cost-effective, and sustainable therapeutic agents that could serve as alternatives to synthetic drugs, particularly in regions where access to modern healthcare is limited.

A rapid and efficient method has been developed for the synthesis of pyrazolo[3,4-d]pyrimidines (5a-j) via microwave assisted method as well as conventional method using four components system in the presence of ionic liquid 2-methyl-imidazolium thiocyanate as a green catalyst. It was found that ionic liquid showed better reactivity than p-toluene-sulfonic acid (p-TSA) and L-proline. All the synthesized pyrazolo-pyrimidine derivatives were characterized by FT-IR, 1H NMR, 13C NMR spectral and elemental analysis. Further, the in vitro anti-breast cancer activity was evaluated by performing cytotoxicity studies against MCF-7 cell lines at different concentrations of synthesized compounds ranging from 100 to 500 µg/mL. Among the series of compounds, compounds 5a and 5d showed significant cytotoxic effect at the lowest concentration. However, all the synthesized compounds proved to be efficient against inhibiting breast cancer cells.

Introduction: Chronic and acute wounds remain a significant burden in clinical settings, frequently complicated by infection, delayed healing, and poor patient adherence. Traditional dressings primarily act as protective barriers and provide minimal active support to the wound environment. In recent years, herbal- based polymeric films have gained attention as innovative dressings that combine the therapeutic benefits of plant-derived compounds with advances in biomaterial design. Methods: A systematic review was carried out in accordance with PRISMA 2020 guidelines using PubMed, Scopus, Web of Science, and Science Direct. Relevant studies on herbal-loaded polymeric films for wound healing were selected based on predefined criteria, and findings were qualitatively analyzed due to variations in study design and materials. Results: A total of 101 studies met the inclusion criteria. Overall, herbal-based polymeric films showed encouraging outcomes, with reported wound closure rates of 75-95% within 14 days. Improvements included better collagen formation, faster epithelialization, and antimicrobial activity with inhibition zones ranging from 15-25 mm against common pathogens. Advanced platforms such as electrospun nanofibers, 3D-printed scaffolds, and stimuli-responsive systems demonstrated controlled drug release and enhanced tissue repair. Discussion: The combined effect of polymers and herbal bioactives appears to strengthen antimicrobial action, regulate inflammation, and promote tissue regeneration. However, concerns regarding standardization, formulation stability, regulatory pathways, and limited clinical trials remain important challenges. Conclusion: Herbal-based polymeric films offer a promising and sustainable approach to modern wound management, though further refinement and clinical validation are necessary for routine clinical adoption.