In this study, the seismic behavior of regular and irregular composite moment resisting frame (CMRF) buildings was investigated. To this aim, 5, 8, 10, 13 and 15-story CMRFs having concrete filled steel tube columns and composite beams were designed at high ductility level and their performances were evaluated comparatively. The case study CMRF structures were categorized into two groups as regular and irregular in elevation. Examined irregular structures have setbacks in different story levels. During the design and performance analysis, SeismoStruct software was employed. Nonlinear static pushover and incremental dynamic analyses were used in the seismic performance assessment. The uniform and triangular load distributions were considered in the pushover analysis while a total of 22 earthquake acceleration records were utilized in the dynamic analysis. The variation in the lateral response, global yielding value, interstory drift, behavior factor, inherent strength factor, overstrength factor, and ductility factor were examined for the regular and irregular CMRF structures. It was observed that the regular CMRFs were more consistent with the design assumptions as compared to the irregular ones. Moreover, the former exhibited more uniform non-elastic demands over the building height according to the results of the incremental dynamic analysis. Under the seismic scenario adopted, all the building types yielded higher values of the behavior factor complied with the limits available in the code.