Fine migration is a serious problem in petroleum reservoir that causes damage to the reservoir and production equipment. One of the methods to solve this problem is using nanotechnology. Nanoparticles can reduce fine migration by various mechanisms such as reducing the zeta potential, changing the total interaction energy between surfaces, pH, and roughness of the particle’s surfaces. This study presents a review of the methods such as sand pack test, core flood test, and proppant test that study the nanoparticles’ influence on fine migration. Also, there are two different scenarios for the use of nanoparticles to mitigate fine migration. One of these scenarios is the co-injection of nanoparticles and particles suspended fluid, and another scenario is the initial injection of nanoparticles into the porous media (pre-flush). The results of the studies have shown that pre-flush of nanoparticles has a better effect on the control of fine migration.

Formation damage is an essential part of drilling and production evaluation, which has a significant effect on well productivity and economics. Drilling fluids are significant sources of formation damage by different mechanisms. This article reviews the research works published during the past 30 years on formation damage associated with drilling fluids, including mechanical damage, chemical damage, and interaction with reservoir rock and fluids. Different filtration techniques, fines migration, and invasion models are discussed based on past studies and recent advancements. Laboratory experiments, methodology, and various aspects of evaluation are considered for further study. Despite presenting different authors’ views and experiences in this area, there is no integrated approach to evaluate formation damage caused by drilling fluids. Finally, the authors analyze the knowledge gap and conclude that a methodology must be designed to improve drilling fluids to prevent formation damage. Recent advances in the area of nanotechnology show promising alternatives for new methods to prevent formation damage.

The kinetic parameters of adenosine deaminase such as Km and Ki were determined in the absence and presence of adenine derivatives (R1-R24) in sodium phosphate buffer (50 mM; pH 7.5) solution at 27 degrees C. These kinetic parameters were used for QSAR analysis. As such, we found some theoretical descriptors to which the binding affinity of adenosine deaminase (ADA) towards several adenine nucleosides as inhibitors is correlated. QSAR analysis has revealed that binding affinity of the adenine nucleosides upon interaction with ADA depends on the molecular volume, dipole moment of the molecule, electric charge around the N1 atom, and the highest of positive charge for the related molecules.