Kyoung-Kon Kim, Ji-Hee Haam, Bom Taeck Kim, Eun Mi Kim, Jung Hwan Park, Sang Youl Rhee, Eonju Jeon, Eungu Kang, Ga Eun Nam, Hye Yeon Koo, Jeong-Hyun Lim, Jo-Eun Jeong, Jong-Hee Kim, Jong Won Kim, Jung Ha Park, Jun Hwa Hong, Sang Eok Lee, Se Hee Min, Seung Jun Kim, Sunyoung Kim, Yang-Hyun Kim, Yeon Ji Lee, Yoon Jeong Cho, Young-Jun Rhie, Youn-hee Kim, Jee-Hyun Kang, Chang Beom Lee, Committee of Clinical Practice Guidelines, Korean Society for the Study of Obesity (KSSO). J Obes Metab Syndr 2023;32:1-24. https://doi.org/10.7570/jomes23016

Obesity is one of the well-known risk factors of breast cancer. We evaluated the relationship between serum adiponectin and resistin levels and breast cancer risk in 41 biopsy-proven breast cancer patients and 43 age- and body mass index-matched controls. The mean serum adiponectin level was lower in the breast cancer group than the control group (6.93+/-3.2 microg/mL, vs. 7.60+/-3.5 microg/mL), but this difference did not reach statistical significance (p=0.37). There was a statistically significant difference in serum resistin levels between the groups (breast cancer group 5.23+/-6.9 ng/mL vs. control 1.46+/-2.0 ng/mL; p<0.001). The risk of breast cancer was significantly increased in the highest tertile group for serum resistin level compared to the lowest tertile group (adjusted odds ratio 2.77 [95% CI 1.40-5.50]). The lymph node metastasis was significantly increased in the patients with less than the median adiponectin level (p=0.017). In the patients whose resistin level was higher than the median, the frequency of tumor with the highest histological grade was significantly increased (p=0.025). In conclusions, both the low serum adiponectin levels and high resistin levels are likely to be associated with increased breast cancer risk in Korean women.

Kyoung-Kon Kim, Jee-Hyun Kang, Eun Mi Kim. J Obes Metab Syndr 2022;31:230-44. https://doi.org/10.7570/jomes22050

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