Increasing numbers of patients who recover from COVID-19 report lasting symptoms, such as fatigue, muscle weakness, dementia, and insomnia, known collectively as post-acute COVID syndrome or long COVID. These lasting symptoms have been examined in different studies and found to influence multiple organs, sometimes resulting in life-threating conditions. In this review, these symptoms are discussed in connection to the COVID-19 and long-COVID-19 immune changes, highlighting oral and psychiatric health, as this work focuses on the gut microbiota’s link to long-COVID-19 manifestations in the liver, heart, kidney, brain, and spleen. A model of this is presented to show the biological and clinical implications of gut microbiota in SARS-CoV-2 infection and how they could possibly affect the therapeutic aspects of the disease. Probiotics can support the body’s systems in fighting viral infections. This review focuses on current knowledge about the use of probiotics as adjuvant therapies for COVID-19 patients that might help to prevent long-COVID-19 complications.

This study was performed to assess changes in diffusion tensor imaging (DTI) over time in patients with amyotrophic lateral sclerosis (ALS). We performed DTI in 23 ALS patients who had two magnetic resonance imaging (MRI) scans at 6 month intervals and to correlate results with clinical features. The revised ALS functional rating scale (ALSFRS–R) was administered at each clinical visit. Data analysis included voxel–based white matter tract–based spatial statistics (TBSS) and atlas–based region–of–interest (ROI) analysis of fractional anisotropy (FA) and mean diffusivity (MD). With TBSS, there were no significant changes between the two scans. The average change in FA and MD in the ROIs over 6 months was small and not significant after allowing for multiple comparisons. After allowing for multiple comparisons, there was no significant correlation of FA or MD with ALSFRS–R. This study shows that there is little evidence of progressive changes in DTI over time in ALS. This could be because white matter is already substantially damaged by the time of onset of symptoms of ALS.

Due to the recent evolution of telecommunications, it is now acknowledged that digital communication provides essential services for remote areas. Teleradiology allows the ability to obtain images at one site, send them over a distance, and view them remotely for diagnostic or consultation purposes. The highlighted objectives include (a) the added value of the service, (b) user satisfaction, and (c) quality assurance according to global best practices and national quality standards. This study utilised an eight-part online self-report survey distributed among employees of the Ministry of Health (MOH) who use the national teleradiology platform. The survey sections were designed to gather comprehensive data, including participant demographics, levels of satisfaction with the service, awareness of security measures, communication effectiveness, perceived advantages and disadvantages, quality assurance, technical challenges, IT support, and future perceptions of teleradiology services. Additionally, a total of 212 MRI reports from patients who underwent brain and spine MRI examinations between 2018 and 2020 were collected from the platform to strengthen the analysis. Most survey respondents (78%) were males, with a significant majority (96.2%) affirming that teleradiology sufficiently addresses clinical inquiries. Furthermore, 90% expressed satisfaction with the service, and 93% endorsed the standardization of MR imaging procedures across Ministry of Health (MOH) hospitals. Notably, 92.4% recognised teleradiology as a transformative strategy for healthcare facilities in Saudi Arabia, concurring with its benefits. The analysis of the MRI reports revealed structural inconsistencies; compared with structured templates, the average number of incorporated elements was reduced, and essential elements were frequently absent. Intriguingly, reports delineating normal cases included a higher incidence of clinical impressions relative to those describing abnormalities, yet the latter contained a more comprehensive array of elements. Variability in report composition was correlated with the years of experience of the reporters. Teleradiology users perceived enhancements in the quality of radiological reporting and the daily operational workflow. Nonetheless, certain limitations were identified, necessitating focused improvements by service providers. Despite teleradiology being a subspecialisation, it can reduce the role of local radiologists. Further research is needed on data security, confidentiality, and archiving options, as well as the cost-effectiveness of teleradiology services.

Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by loss of upper and lower motor neurons. There is a need for an imaging biomarker to track disease progression. Previously, magnetic resonance imaging (MRI) has shown loss of grey and white matter in the brain of patients with ALS compared to controls. We performed serial diffusion tractography imaging (DTI) study of patients with ALS looking for changes over time.Methods: On all subjects (n = 15), we performed three MRI studies at 6 month intervals. DTI changes were assessed with tract-based spatial statistics (TBSS) and region of interest (ROI) studies. Cortic-spinal tract (CST) was selected for our ROI at the upper level; the posterior limb of internal capsule (PLIC), and a lower level in the pons.Results: There was no significant change in DTI measures over 12 months of observation. Better correlation of manual and atlas-based ROI methods was found in the posterior limb of the internal capsule than the pons.Conclusion: While previous DTI studies showed significant differences between ALS subjects and controls, within individual subjects there is little evidence of progression over 12 months. This suggests that DTI is not a suitable biomarker to assess disease progression in ALS.