ZnIn₂S₄, a novel two-dimensional visible light-responsive photocatalyst, has attracted much attention in the photocatalytic evolution of H₂ under visible light irradiation due to its attractive intrinsic photoelectric properties and geometric configuration. However, ZnIn₂S₄ still has severe charge recombination, which results in moderate photocatalytic performance. Herein, we report the successful synthesis of 2D/2D ZnIn₂S₄/Ti₃C₂ nanocomposites by a facile one-step hydrothermal method. The efficiency of the nanocomposites in photocatalytic hydrogen evolution under visible light irradiation was also evaluated for different ratios of Ti₃C₂, and the optimal photocatalytic activity was achieved at 5% Ti₃C₂. Importantly, the activity was significantly higher than that of pure ZnIn₂S₄, ZnIn₂S₄/Pt, and ZnIn₂S₄/graphene. The enhanced photocatalytic activity is mainly due to the close interfacial contact between Ti₃C₂ and ZnIn₂S₄ nanosheets, which amplifies the transport of photogenerated electrons and enhances the separation of photogenerated carriers. This research describes a novel approach for the synthesis of 2D MXenes for photocatalytic hydrogen production and expands the utility of MXene composite materials in the fields of energy storage and conversion.

The so-far used Ga-68- or F-18-labelled tracers are of a relative short time window in differentiating tumor fibrosis. SPECT applicable imaging probe, ^99mTc-HYNIC-FAPI-04, was synthesized and evaluated in tumor cells and animal models of FAP-positive glioma and FAP-negative hepatoma, and then compared with ¹⁸F-FDG or ⁶⁸Ga-FAPI-04 PET/CT. The radio-labeling rate of ^99mTc-HYNIC-FAPI-04 was greater than 90%, and the radiochemical purity was >99% after purification with sep-pak C18 column. In vitro cell uptake experiments of ^99mTc-HYNIC-FAPI-04 showed good FAP binding specificity, and the cellular uptake significantly decreased when blocked by DOTA-FAPI-04, reflecting the similar targeting mechanism of HYNIC-FAPI-04 and DOTA-FAPI-04. SPECT/CT imaging showed that U87MG tumor was distinguishable and of a high uptake of ^99mTc-HYNIC-FAPI-04 (2.67 ± 0.35 %ID/mL at 1.5 h post injection (h P.I.), while tumor signal of FAP-negative HUH-7 was as low as 0.34 ± 0.06 %ID/mL. At 5 h P.I., U87MG tumor was still distinguishable (1.81 ± 0.20 %ID/mL). In comparison, although U87MG tumor was of obvious ⁶⁸Ga-FAPI-04 uptake and clearly visible at 1 h P.I., the tumorous radioactive signals were fuzzy at 1.5 h P.I. ^99mTc-HYNIC-FAPI-04 specifically bound to FAP-positive tumors and qualified with the ability of evaluating tumor fibrosis over longer time windows.