Objective: We probed into the significance of METTL3 in the maturation process of pri-miR-21-5p. We specifically investigated its impact on the regulation of FDX1 and its involvement in the progres... Plain language summary We investigated a protein called METTL3, which is overly active in lung cancer cells, and how it affects the function of other small molecules. We discovered that as the acti... Tweetable abstract METTL3 aids NSCLC progression by boosting miR-21-5p maturation, targeting FDX1. Understanding this can open new NSCLC treatment avenues. Graphical abstract