The reaction flywheel is a crucial operational component within a satellite’s attitude control system. Enhancing the performance of the reaction flywheel speed control system holds significant importance for satellite attitude control. In this paper, an active disturbance rejection control (ADRC) approach is introduced to mitigate the impact of uncertain disturbances on reaction flywheel speed control precision. The reaction flywheel speed control system is designed as an ADRC controller due to the current challenge of measuring unknown disturbances accurately in the reaction flywheel system. To derive the rotor’s speed observation value and the estimated total disturbances value, the sampled data of the reaction flywheel rotor position and torque control signal are fed into the extended state observer. The estimated total disturbances value is compensated on feedforward control, which could mitigate significantly the effects of various nonlinear disturbances. The paper initially establishes the rationale behind the reaction flywheel ADRC controller through theoretical analysis, followed by analysis of the differences of performance of reaction flywheel control by the ADRC controller and the PID controller in MATLAB/SIMULINK. Simulation results demonstrate the evident advantages of the ADRC controller over the PID controller in terms of speed command tracking capability and disturbances suppression ability. Subsequently, the ADRC controller program and the PID controller program are implemented on the reaction flywheel control circuit, and experiments are conducted to contrast speed command tracking and disturbance suppression. Importantly, the experimental outcomes align with the simulation results.