In numerous environmental compartments around the world, the existence of micro- and nanoplastics (MNPs) in the environment has been verified. A growing number of studies have looked at the interaction between MNPs and human activities due to the risks they may pose to humans. Exposure pathways are key factors in measuring MNPs risks. However, current research largely ignores the contribution of mechanical fragmentation pathways to MNPs exposure during the daily use of plastic products. Our critical review demonstrated the research gap between MNP fragmentation and risk assessments via a network analysis. The release of fragmented MNPs and their properties were also described at various scales, with emphasis on environmental stressors and mechanical fragmentation. In the scenarios of daily use, plastic products such as food packaging and clothing provide acute pathways of MNPs exposure. The release tendency of those products (up to 10² mg MNPs) are several orders of magnitude higher than MNPs abundances in natural compartments. Despite the limited evidence available, waste recycling, landfill and municipal activities represented long-term pathways for MNPs fragmentation and point sources of MNPs pollution in environmental media. Assessing the health effects of the fragmentation process, unfortunately, is further hampered by the current absence of human exposure impact assessments for secondary MNPs. We proposed that future studies should integrate aging evaluation into risk assessment frameworks and establish early warning signs of MNPs released from plastic products.