Natural antioxidant polyphenolic compounds obtained from different plants are considered antioxidants for curing various chronic pathological diseases such as cardiovascular disorders and cancer. Quercetin (a polyphenolic flavonol) has attracted much attention from dietitians and medicinal chemists due to its wide variety of pharmacological activities, including anti-diabetic, anti-hypertensive, anti-carcinogenic, anti-asthmatic, anti-viral, and antioxidant activities. Furthermore, structurally, it is well suited to stabilize emulsions. The present review depicts the important role of the quercetin nanoemulsion technique, used to enhance the solubility of target materials both in vivo and in vitro as well as to decrease the risk of degradation and metabolism of drugs. Researchers have used cryo-TEM to study the morphology of quercetin nanoemulsions. The effects of various parameters such as pH, salts, and solvent concentration on quercetin nanoemulsion have been investigated for quercetin nanoemulsion. Many studies have used UV–Vis spectroscopy and HPLC for the characterization of these particles such as solubility, stability, and encapsulating efficiency.