Donepezil hydrochloride containing polyurethane/hydroxypropyl cellulose (PU/HPC) nanofibers were prepared by the electrospinning for transdermal drug delivery. PU/HPC nanofibers were characterized with SEM, DSC, and Pascal mercury porosimetry. Drug–excipient interaction was studied by ATR-FTIR. In vitro release of PU/HPC nanofiber mat (10:2:1) exhibited Korsmeyer–Peppas release kinetics controlled by the diffusion of drug. In vitro permeation studies across skin resembling synthetic membrane demonstrated the flux of model drug. The in vitro cytotoxicity data obtained via MTT assay indicated that PU/HPC nanofiber mat could be well tolerated by the skin and the components was not irritant for the skin.

The effects of conductive polymers on conductivities and morphologies of electrospun fabrics are analyzed. The factors that affect the conductivities and morphologies are discussed. Some applications of these conductive nanofibers are reported. The introduction of conductive polymers into nanofiber mats has the potential to provide sufficient conductivity for many applications. An improved conductivity can be achieved by maximizing the content of conjugated polymers. The selection of conductive and carrier polymers, solvents, doping agents, oxidizing agents and ratios of them are also important to obtain sufficient properties. Carbon fiber, carbon black and carbon nanotubes are not covered in this review.