(1) Background: Temporomandibular disorders (TMD) signs and symptoms affect the quality of life of patients because they impose an incapacity to participate in daily life activities, causing both physical and psychological discomfort. This review aims to provide the most accurate, comprehensive, and up-to-date description of all information available regarding OHRQoL in TMD. (2) Methods: A systematic search of articles from January 2013 till August 2023 was performed on five databases to identify articles, including TMD and oral health-related quality of life. Two calibrated reviewers performed the search following inclusion and exclusion criteria. A manual search of reference articles was also performed. The data were analyzed qualitatively by combining a meta-analysis and GRADE evidence. The Newcastle–Ottawa scale for cross-sectional and case-control studies was utilized to assess the quality of the included studies. (3) Results: The initial search consisted of 738 articles without the removal of duplicates. Fifteen articles were included in this systematic review, and ten were included in the meta-analysis. Almost all the included observational studies reported poor OHRQoL among patients with different types of TMD. The results of the meta-analysis with a standard mean difference (SMD) and that included seven studies suggest high heterogeneity with I² = 99%, SMD (95% CI) = 3.18 (1.90, 4.46), p-value < 0.01. The odds ratio analyzed for three included articles in the meta-analysis reported statistical significance (p-value < 0.01) with OR = 8.21 (2.39, 28.25) and a heterogeneity of 86%. The certainty of evidence by GRADE resulted in a downgraded level of evidence, indicating that the OHRQoL of TMD patients may differ slightly from the healthy controls. (4) Conclusions: The impact of OHRQoL on the TMD was deemed to be significant. Overall, the OHRQoL is low for any type and intensity of pain among TMD patients and controls.

Background: This systematic review examines and evaluates the relationship between salivary cortisol levels and temporomandibular disorder (TMD) in young adult patients. Method: Six databases—PubMed, Scopus, Web of Science, Google Scholar, ProQuest, and Cochrane Library—were utilized to screen eligible studies. A systematic search was performed based on PECO questions and eligibility criteria. The research question for this review was “Do salivary cortisol levels correlate with TMD in individuals aged 18–40?” The risk of bias for quality assessment was determined by the Cochrane tool. PRISMA guidelines were followed while performing this review. Result: A total of fourteen studies were included in this review. Of these, eleven were observational studies (four cross-sectional and seven case–control), and three were randomized control trials. Eleven of the included studies presented a low to moderate risk in the qualitative synthesis. The total sample size of the included studies was 751 participants. The included studies suggest higher salivary cortisol levels in TMD patients than in healthy individuals. Conclusions: The findings of this review indicate higher salivary cortisol levels in adult patients with TMD than in healthy controls. Thus, supportive psychological treatment and clinical modalities should be provided to patients with TMD. Moreover, higher-quality studies with low heterogeneity are required to support this finding.

Background/Objectives: This study aims to evaluate the impact of temporomandibular disorders (TMDs) on oral health-related quality of life (OHRQoL), determine the effects of different influencing factors, and identify the most affected dimensions among the Saudi Arabian population. Methods: A cross-sectional study was conducted among 110 individuals visiting the Department of Oral Medicine at the Dental University Hospital (DUH), King Saud University. Participants were equally categorized into two groups: TMD and controls. The diagnosis was based on the Diagnostic Criteria for Temporomandibular Disorders (DC/TMDs). OHRQoL was assessed using the OHIP-TMD scale. Statistical analyses included independent t-tests, chi-square tests, and multivariate regression models to evaluate the association between TMD and OHRQoL. Results: The study population consisted of 72.7% females, with 91.8% holding a degree and 81.8% being married. TMD patients showed significantly lower OHRQoL scores in all domains (p ≤ 0.05), with the most pronounced impairments observed in terms of physical pain and psychological discomfort (p = 0.000). Marital status was a significant predictor of OHRQoL (p = 0.02; OR = 0.277), whereas gender and education showed no significant associations. Conclusions: TMD is significantly associated with impaired OHRQoL, particularly in the domains of physical pain and psychological discomfort. Marital status emerged as a significant demographic factor influencing OHRQoL. Given the cross-sectional nature of this study, the findings highlight associations rather than causation. Future longitudinal studies are recommended to establish causal relationships and further investigate the biopsychosocial impact of TMD on quality of life.

Background: Radiotherapy and bone-modifying agents are widely used to treat malignancies and metastases. Bone-modifying agents and radiation-related adverse effects on oral health detrimentally affect dental treatment outcomes. Two common complications occur during and after radiotherapy: bone-modifying medications, osteoradionecrosis, and osteonecrosis of the bones. Dental professionals play an important role in evaluating procedures that can potentially cause these complications. Objective: This systematic review aimed to evaluate the effects of dental treatment on oral health in patients who had received radiotherapy and bone-modifying agents. Methods: A comprehensive search was conducted using PubMed, Scopus, Web of Science, Embase, Medline, Proquest, and Cochrane Library from 2015-2023 following PRISMA guidelines. Results: Eighteen articles, published between 2015 and 2023, were reviewed. Dental implants have been the main focus of attention in most studies, as radiation therapy can reduce the microhardness of enamel and dentin and increase the risk of osteoradionecrosis (ORN) and tooth failure. However, dental implants can still be successful with proper bone quality and implant techniques, and bisphosphonate therapy does not significantly affect implant failure. Conclusion: The risk of developing osteonecrosis was not significant, but was increased by parenteral administration compared with oral administration. Bisphosphate is associated with deep pockets, higher bleeding index, and pulp obliteration.