Guoping Chen

Prof. Guoping Chen

Research Center for Functional Materials, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 3050044, Japan
orcid

Research Focus & Metrics

Academic Career Length

31Years (1996-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 July 2004 in Biochemical and Biophysical Research Communications
Verified
Journal Article
Closed access
NINitaya Indrawattana
Nitaya Indrawattana
GCGuoping Chen
Guoping Chen
MTMika Tadokoro
Mika Tadokoro
LSLinzi H Shann
Linzi H Shann
HOHajime Ohgushi
Hajime Ohgushi
ABAhnond Bunyaratvej
Ahnond Bunyaratvej

22 October 2018 in Frontiers in Chemistry
Verified
Journal Article
Open access
XLXiaomeng Li
Xiaomeng Li
QSQingqing Sun
Qingqing Sun
QLQian Li
Qian Li
NKNaoki Kawazoe
Naoki Kawazoe
GCGuoping Chen
Guoping Chen
Tissue engineering (TE) has been used as an attractive and efficient process to restore the original tissue structures and functions through the combination of biodegradable scaffolds, seeded cells, and biological factors. As a unique type of scaffolds, hydrogels have been frequently used for TE because of their similar 3D structures to the native extracellular matrix (ECM), as well as their tunable biochemical and biophysical properties to control cell functions such as cell migration, adhesion, proliferation, and differentiation. Various types of hydrogels have been prepared from naturally derived biomaterials, synthetic polymers, or their combination, showing their promise in TE. This review summarizes the very recent progress of hydrogels used for TE applications. The strategies for tuning biophysical and biochemical properties, and structures of hydrogels are first introduced. Their influences on cell functions and promotive effects on tissue regeneration are then highlighted.

1 May 2014 in Acta Biomaterialia
Verified
Journal Article
Closed access
QZQin Zhang
Qin Zhang
HLHongxu Lu
Hongxu Lu
NKNaoki Kawazoe
Naoki Kawazoe
GCGuoping Chen
Guoping Chen

28 October 2010 in Expert Opinion on Biological Therapy
Verified
Journal Article
Closed access
THTakashi Hoshiba
Takashi Hoshiba
HLHongxu Lu
Hongxu Lu
NKNaoki Kawazoe
Naoki Kawazoe
GCGuoping Chen
Guoping Chen
(2010). Decellularized matrices for tissue engineering. Expert Opinion on Biological Therapy: Vol. 10, No. 12, pp. 1717-1728.

1 January 2012 in Acta Biomaterialia
Verified
Journal Article
Closed access
WZWanyin Zhai
Wanyin Zhai
HLHongxu Lu
Hongxu Lu
LCLei Chen
Lei Chen
XLXiaoting Lin
Xiaoting Lin
YHYan Huang
Yan Huang
JCJiang Chang
Jiang Chang

26 July 2016 in Polymers
Verified
Journal Article
Open access
PDF file
XLXiaomeng Li
Xiaomeng Li
SCShangwu Chen
Shangwu Chen
JLJingchao Li
Jingchao Li
XWXinlong Wang
Xinlong Wang
JZJing Zhang
Jing Zhang
GCGuoping Chen
Guoping Chen
Gelatin hydrogels can mimic the microenvironments of natural tissues and encapsulate cells homogeneously, which makes them attractive for cartilage tissue engineering. Both the mechanical and biochemical properties of hydrogels can affect the phenotype of chondrocytes. However, the influence of each property on chondrocyte phenotype is unclear due to the difficulty in separating the roles of these properties. In this study, we aimed to study the influence of hydrogel stiffness on chondrocyte phenotype while excluding the role of biochemical factors, such as adhesion site density in the hydrogels. By altering the degree of methacryloyl functionalization, gelatin hydrogels with different stiffnesses of 3.8, 17.1, and 29.9 kPa Young’s modulus were prepared from the same concentration of gelatin methacryloyl (GelMA) macromers. Bovine articular chondrocytes were encapsulated in the hydrogels and cultured for 14 days. The influence of hydrogel stiffness on the cell behaviors including cell viability, cell morphology, and maintenance of chondrogenic phenotype was evaluated. GelMA hydrogels with high stiffness (29.9 kPa) showed the best results on maintaining chondrogenic phenotype. These results will be useful for the design and preparation of scaffolds for cartilage tissue engineering.