Background: We aimed to address which interventions best control blood pressure (BP) and delay disease progression in prehypertension and to give recommendations for the best option following a quality rating.Methods: A Bayesian network meta-analysis was used to assess the effect of the intervention on BP reduction, delaying hypertension progression and final outcome, with subgroup analyses for time and ethnicity. Recommendations for interventions were finally based on cumulative ranking probabilities and CINeMA.Results: From 22,559 relevant articles, 101 eligible randomized controlled trial articles (20,176 prehypertensive subjects) were included and 30 pharmacological and non-pharmacological interventions were evaluated. Moderate-quality evidence demonstrated that angiotensin II receptor blockers, aerobic exercise (AE), and dietary approaches to stop hypertension (DASH) lowered systolic blood pressure (SBP). For lowering diastolic blood pressure (DBP), AE combined with resistance exercise (RE) or AE alone provided high quality evidence, with calcium channel blockers, lifestyle modification (LSM) combined with drug providing moderate quality evidence. LSM produced the best BP lowering effect at 12 months and beyond of intervention. In Asians, TCD bubble was moderate quality evidence for lowering SBP and RE may have had a BP lowering effect in Caucasians. No recommendation can be given for delaying the progression of hypertension and reducing mortality outcomes because of low to very low quality of evidence.Conclusion: AE combined RE are preferentially recommended for BP control in prehypertension, followed by DASH. Long-term BP control is preferred to LSM. Asians and Caucasians add TCD bubble and RE to this list as potentially effective interventions.Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022356302, identifier: CRD42022356302.

Background: Functional dyspepsia is one of the most common functional gastrointestinal disorders that affects the physical health and quality of life of many people. Its status as a chronic disease has received continued attention in the field of gastrointestinal research.Objective: Bibliometric methods using network analysis were used to identify developments and research trends in functional dyspepsia with a view to informing and orienting further in-depth research on functional dyspepsia.Method: Bibliometric methods were used to analyze the documents on functional dyspepsia published from 2002 to 2022 retrieved from Web of Science Core Collection on 1 July 2022, import literature data into Excel and VOSviewer, and extract relevant information to analyze and visualize the annual number of publications, authors, organizations, countries, journals published, citations, and keywords.Results: A total of 3,532 documents were retrieved, and the abstracts of each remaining documents were read one by one after four duplicate documents were removed, and 2,220 documents were included after screening, with a fluctuating growth trend. Tack J ranked first with 171 documents, followed by Talley NJ (n = 167). The top three organizations in terms of number of publications were Katholieke Universiteit Leuven (n = 131), Mayo Clinic (n = 127), and the University of Newcastle (n = 91). The most prolific country was the United States with 499 documents. The three journals with the highest number of publications are “Neurogastroenterology and Motility” (n = 218), “Alimentary pharmacology & therapeutics” (n = 101), and “Journal of Gastroenterology and Hepatology” (n = 90). The top three most cited documents were “Functional gastroduodenal disorders,” “Childhood Functional Gastrointestinal Disorders: Child/Adolescent,” and “The Serotonin Signaling System: From Basic Understanding to Drug Development for Functional GI Disorders.” Frequency counts and network co-occurrences of keywords reveal trends in this field, including “gastric emptying,” “anxiety,” “acupuncture,” and “ghrelin.”Conclusion: The study of the mechanism of gut–brain interaction in functional dyspepsia and the combination of non-pharmacological treatment and pharmacological treatment may be the future research hotspots and trends. Our findings are helpful to comprehensively review the research history of FD and provide reference for researchers in this field to further study.

Emotional contagion, that is, the spontaneous synchronization of emotions among individuals, is the basic mechanism of social cohesion and survival of different species. Emotional contagion can be observed in humans and many animals, and it has become an effective means to protect individuals from danger. The study of emotional contagion in different animals is of evolutionary significance, and in human society, emotional contagion has an important impact on mental health and group behavior. However, the existing research still has obvious shortcomings in the similarities and differences of cross-species emotional contagion, the communication dynamics in virtual space and the infectious effect of positive emotions. This paper reviews the mechanisms of emotional contagion in different species, such as rodents, nonhuman primates, dogs, crows and zebrafish, highlighting evolutionary conservatism and species-specific adaptation, and analyzes the role of human children's behavioral mimicry in its early development. Furthermore, we extend the discussion of emotional contagion to virtual social networks, revealing the unique communication mechanism in online environment. In addition, by combing the sociological model and the emerging neurocognitive model, the complex process of emotional contagion can be explained more comprehensively. Through multidisciplinary perspective, it provides systematic theoretical and empirical support for us to understand emotional contagion.

Aims: To describe the details of dyadic interventions and summarize the current evidence on supporting dyadic interventions for psycho-social outcomes of stroke patients and their caregivers.Design: A systematic review and meta-analysis based on PRISMA guidelines.Data sources: Five English databases (PubMed, Web of Science, CINAHL, Embase and Cochrane Library) were searched to identify eligible studies published from the inception to October 15, 2024.Methods: Two reviewers independently screened the literature in accordance with the selection criteria. The risk of bias of the included studies was assessed using Cochrane RoB 2.0. Relevant information was extracted, narrative synthesis was conducted and the meta-analysis was carried out using Review Manager 5.4 soft.Results: A total of 28 literature were identified and included in this review. These interventions focused mainly on the provision of stroke related knowledge, promotion of family relationships and relief of negative emotions by a face-to-face mode. The outcome indicators can be grouped into three dimensions based on the developmental contextual coping model: dyadic appraisal, dyadic coping and dyadic adjustments. The results of meta-analysis showed that dyadic interventions significantly improved quality of life and coping capacity of patients, promoted family function of caregivers and alleviated caregiver-related burden.Conclusion: These findings highlighted the positive outcomes of dyadic interventions that focused on patients and their caregivers coping with stroke. However, the effectiveness of interventions is not absolute, the evaluation system of intervention effect needs to be improved and demand-driven interventions need to be developed urgently. Therefore, further large-scale randomized controlled trials with a high-quality design are warranted.Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/, CRD42024621297.

Background: Functional dyspepsia (FD) as a type of disorders of brain-gut interaction (DBGI), patient self-reporting of its symptoms becomes an important component of clinical outcome assessment. We performed a systematic review using Consensus Based Standards for the Selection of Health Measurement Instruments (COSMIN) guidelines to identify the best available patient-reported outcome measure (PROM) of FD. Methods: The study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We searched four databases with no date limit, looking for previously confirmed PROMs for evaluating FD symptoms. An overall rating was then assigned based upon COSMIN guidelines, and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach was used to assess the level of evidence for psychometric properties of included PROMs. Results: Thirty articles covering outcome indicators of 24 patient reports were included. The Leuven Postprandial Distress Scale (LPDS) showed adequate content validity and moderate quality evidence of adequate internal consistency to generate an A recommendation. Conclusion: LPDS is currently the most recommended PROM for patient self-reported FD symptoms. However, it fails to assess two important areas of cross-cultural validity/ measurement invariance and measurement error. Future research can be continuously improved on this basis.

The aim of this study was to evaluate the hypotensive effect and optimal protocol of inspiratory muscle resistance training (IMST). Randomized controlled trials using IMST to lower blood pressure (BP) were retrieved from 12 databases as of July 2022. A meta‐analysis of BP and heart rate variability (HRV) was performed and a trial sequence analysis was performed using trial sequential analysis (TSA) software. Twelve articles (n = 386 participants) from five countries were included, with a mean quality score of 5.83. IMST achieved significant results in reducing systolic, diastolic, and mean arterial pressure (−7.93 [−12.08, −3.78]; −3.80 [−6.08, −1.53]; −4.90 [−13.76, 3.96]). Furthermore, TSA has shown that the findings for systolic and diastolic BP are conclusive. Finally, considerable variation remained between studies when analyzing HRV. The overall hypotensive effect of IMST was demonstrated by the TSA and was well tolerated in different populations. Of these, two interventions, high resistance or low resistance combined with slow breathing, showed the best efficacy under an 8‐week exercise intervention. In addition, the process of lowering BP by modulating sympathetic vagal activity has not been further confirmed in this study. Future long‐term interventions, especially those over 3 months, are needed to observe the prolonged antihypertensive effects and modulatory mechanisms; controlling for variables such as respiratory rate and executing more rigorous studies to further explore antihypertensive options.