Under the action of the flow field force and the constraint reaction force of the negative rotor and the positive rotor, the twin screw compressor shell will produce vibration, which will affect the life of the parts and produce noise. The rotors restraint reaction force are calculated by fluid-structure coupling method. The shell inherent frequency is solved by modal analysis, and the shell resonance is analyzed during the rotors meshing process. On this basis, the flow field force and rotor constraint reaction force are used as the compressor shell vibration excitation sources, and the vibration response of the compressor shell under the action of excitation force is studied. The research results can provide some reference for the optimized design of compressor shell structure.