Prof. Ravinder R Regatte
Center for Advanced Imaging Innovation and Research, New York University Grossman School of Medicine, New York, NY 10016, USA
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Academic Career Length
28Years (1999-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications19 February 2008 in Proceedings of the National Academy of Sciences
Journal Article
WLWen Ling
Wen Ling
Ravinder R RegatteGNGil Navon
Gil Navon
AJAlexej Jerschow
Alexej JerschowGlycosaminogycans (GAGs) are involved in numerous vital functions in the human body. Mapping the GAG concentration in vivo is desirable for the diagnosis and monitoring of a number of diseases such as osteoarthritis, which affects millions of individuals. GAG loss in cartilage is typically an initiating event in osteoarthritis. Another widespread pathology related to GAG is intervertebral disk degeneration. Currently existing techniques for GAG monitoring, such as delayed gadolinium-enhanced MRI contrast (dGEMRIC), T 1 ρ , and 23 Na MRI, have some practical limitations. We show that by exploiting the exchangeable protons of GAG one may directly measure the localized GAG concentration in vivo with high sensitivity and therefore obtain a powerful diagnostic MRI method.
7 March 2006 in Journal of Magnetic Resonance Imaging
Journal Article
Ravinder R RegatteSASarma V.S. Akella
Sarma V.S. Akella
JLJ.H. Lonner
J.H. Lonner
JKJ.B. Kneeland
J.B. Kneeland
RRRavinder Reddy
Ravinder Reddy30 May 2013 in Journal of Magnetic Resonance Imaging
Journal Article
GMGuillaume Madelin
Guillaume MadelinRavinder R RegatteIn this article we present an up‐to‐date overview of the potential biomedical applications of sodium magnetic resonance imaging (MRI) in vivo. Sodium MRI is a subject of increasing interest in translational imaging research as it can give some direct and quantitative biochemical information on the tissue viability, cell integrity and function, and therefore not only help the diagnosis but also the prognosis of diseases and treatment outcomes. It has already been applied in vivo in most human tissues, such as brain for stroke or tumor detection and therapeutic response, in breast cancer, in articular cartilage, in muscle, and in kidney, and it was shown in some studies that it could provide very useful new information not available through standard proton MRI. However, this technique is still very challenging due to the low detectable sodium signal in biological tissue with MRI and hardware/software limitations of the clinical scanners. The article is divided in three parts: 1) the role of sodium in biological tissues, 2) a short review on sodium magnetic resonance, and 3) a review of some studies on sodium MRI on different organs/diseases to date.J. Magn. Reson. Imaging 2013;38:511–529. © 2013 Wiley Periodicals, Inc.
1 May 2014 in Progress in Nuclear Magnetic Resonance Spectroscopy
Journal Article
GMGuillaume Madelin
Guillaume MadelinJLJae-Seung Lee
Jae-Seung LeeRavinder R RegatteAJAlexej Jerschow
Alexej Jerschow1 October 2015 in Osteoarthritis and Cartilage
Journal Article
AGAli Guermazi
Ali GuermaziHAH. Alizai
H. Alizai
MCMichel Daoud Crema
Michel Daoud Crema
Siegfried TrattnigRavinder R RegatteFRF.W. Roemer
F.W. Roemer
1 June 2004 in Radiology
Journal Article
AWAndrew J. Wheaton
Andrew J. WheatonABArijitt Borthakur
Arijitt Borthakur
ESErik M. Shapiro
Erik M. Shapiro
Ravinder R RegatteSASarma V. S. Akella
Sarma V. S. Akella
RRRavinder Reddy
Ravinder Reddy +1
The feasibility of using sodium magnetic resonance (MR) imaging to detect proteoglycan loss in early-stage osteoarthritis is evaluated. Fixed charge density (FCD) maps were calculated from sodium MR imaging data collected in nine healthy volunteers and three individuals with symptoms of early-stage osteoarthritis by using a 4.0-T clinical MR imaging unit. Data from the healthy individuals revealed a mean FCD of -182 mmol/L +/- 9. Data from the symptomatic subjects revealed focal regions of decreased FCD, with mean values ranging from -108 to -144 mmol/L, indicating proteoglycan loss from the cartilage matrix. The data suggest that sodium MR imaging has potential for use as a quantitative diagnostic tool to measure changes in proteoglycan content in early-stage osteoarthritis.
About Me
Dr. Ravinder R. Regatte received a doctoral degree in Physics from Osmania University, Hyderabad, India, in 1996. From 1997 to 2004, he was a Postdoctoral Fellow and Research Associate in the Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA. In 2004, he joined the New
York University School of Medicine, New York, NY, USA, as a Faculty Member, where he currently heads the Quantitative Multinuclear Musculoskeletal Imaging Group, the Center for Biomedical Imaging, Department of Radiology. He is also a Professor of Radiology, working on the development of novel multinuclear (1H, 23Na, 31P, and gagCEST) imaging techniques for early metabolic and biochemical changes in a host of chronic diseases. He has authored or co-authored more than 200 peer-reviewed papers in scientific journals, including the Proceedings of the National Academy of Sciences of the United States of America, Magnetic Resonance in Medicine, NeuroImage, the Journal of Magnetic Resonance Imaging (JMRI), and Radiology. He is currently the Deputy Editor of JMRI. He was recognized for his excellence in medical imaging research and received the 2014 Distinguished Investigator of the Academy of Radiology Research and Biomedical Imaging Research award. He was also elected a fellow of the AIMBE and the ISMRM.