Biopolymers have significant pharmaceutical applications, and their blending has favorable characteristics for their pharmaceutical properties compared to the sole components. In this work, sodium alginate (SA) as a marine biopolymer was blended with poly(vinyl) alcohol (PVA) to form SA/PVA scaffolds through the freeze–thawing technique. Additionally, polyphenolic compounds in Moringa oleifera leaves were extracted by different solvents, and it was found that extracts with 80% methanol had the highest antioxidant activity. Different concentrations (0.0–2.5%) of this extract were successfully immobilized in SA/PVA scaffolds during preparation. The characterization of the scaffolds was carried out via FT-IR, XRD, TG, and SEM. The pure and Moringa oleifera extract immobilized SA/PVA scaffolds (MOE/SA/PVA) showed high biocompatibility with human fibroblasts. Further, they showed excellent in vitro and in vivo wound healing capacity, with the best effect noted for the scaffold with high extract content (2.5%).

Finding renal and hepatoprotective agents preferably with antioxidant activities against environmental pollutants especially lead which can adversely affect liver and kidney is a great demand. In the current study, flaxseed protein isolate (FPI) was extracted from defatted flaxseed meal. Amino acids profile, antioxidant capacity and solubility of the extracted FPI were determined. The solubility of FPI in the acidic media was exploited in preparation of lemon juice with FPI. Twenty four male rats were assigned to four groups; normal control, lead intoxicated (oral daily dose of 60 mg/kg b.w. in distilled water for four weeks), lead intoxicated and orally administrated with daily dose equal 1 ml of lemon juice as well as lead intoxicated and orally administered with FPI (daily dose equal 100 mg/kg) in 1 ml of lemon juice. The oral administration of FPI incorporated in lemon juice suppressed the elevation in kidney functions, lipid peroxidation of kidney tissues, urinary protein and creatinine as well as liver functions caused by lead intoxication. Additionally, lemon juice with FPI combated the reduction of GSH of kidney tissues. It was revealed also that lemon juice without FPI suppressed the elevation in kidney and liver functions caused by lead. It can be concluded that flaxseed protein isolate is a good source of protein with potent antioxidant activity. Additionally, lemon juice and FPI are considered protective sources of kidney and liver against lead toxicity.

Background: There is a worldwide demand for phenolic compounds (PC) because they exhibit several biological activities. The present investigation deals with a comprehensive study on the biological activities of phenolic compounds extracted from flaxseed meal (FM) with the aid of ultrasonic waves. Results: The antioxidant activity of the PC extract of FM is considerably high when measuring it by the three methods (the β-carotene coupled oxidation method, the DPPH free radical scavenging activity method, and measuring the reducing antioxidant power). The toxicity test revealed that the PC extract was nontoxic on normal retina cell line. Also, it has no anticoagulating activity. Evaluation of antimicrobial activity showed that it is effective towards four strains only from seven. FM phenolic extract has been evaluated as chemo-preventive agents by testing the product for any cytotoxic activity against human tumor cell lines. The highest inhibitory effect was achieved on cell lines of colon carcinoma and lung carcinoma with IC₅₀ = 22.3 and 22.6 μ/ml respectively. Conclusion: The PC extracted from FM showed high antioxidant activity, nontoxic on normal retina cell line, no anticoagulating activities, and an antimicrobial effect on some pathogenic bacteria, so the phenolic compounds extracted from flaxseed meal showed significant biological activities.

In the industry, acid and alkali are used to hydrolyze lignocellulosic materials into cellulose and lignin. The cellulose is to be used in several industries such as the production of bioethanol, in the sugar industry, and as carbonaceous materials in place of bleaching agents. On the other hand, the lignin separated from the lignocellulosic materials is used as a rich source of different bioactive materials. Usually, the alkali and acid hydrolysis are carried out at high temperatures. The aim of this study was to carry the extraction by using ultrasound equipment at low temperatures to save the phytochemicals present. This study was designed to investigate the effect of 12 different treatments on the extraction of bioactive compounds from jatropha and jojoba hulls. These bioactive extracts are examined for their phytochemical content, antioxidant, and antibacterial activities. The free and bounded bioactive compounds from jojoba and jatropha hulls were also considered. From our previous work, we reached the conclusion that a single extraction method is not as effective as a mixture of solvents and extraction processes. The hulls were ground and sieved. The effects of ultrasound-assisted extraction together with soaking afterwards were investigated. Solvents used were (1, 0. 5 N HCl), (1, 0.5 N-NaOH), and (70 ml ethanol mixed with 30 ml of (1, 0. 5) N HCl or NaOH) and then soaking to reduce the temperature and to enhance the process in order to hydrolyze lignin. The phenolic compounds, flavonoids, and saponins in each extract were determined, and their antioxidant activities were evaluated. Three antioxidant activity methods were applied for each extract: hydrogen peroxide (H2O2) radical scavenging activity, DPPH, and total reducing capability. Bioactive compounds in their natural form were found to possess high antioxidant activities exceeding that of BHT. The NaOH proved to have a great power for the extraction of phytochemical compounds with elevated antioxidant activities from jojoba, while (1, 0.5 N) HCl with ethanol (30–70%) concentrations extracted phytochemicals with high antioxidant activity from jatropha. (A) A simple method for the extraction of flavonoid, phenolic, and saponin compounds from jojoba and jatropha hulls with different activities has been developed. This method utilized a small amount of solvent and less energy. The bioactive extracts can be used in the pharmaceutical industry. (B) Introduce different structure of bioactive compost extracts from jojoba and jatropha hulls through hydrolyses of lignocellulolytic hulls and then the residue will be ready at the same time for multi-uses in industrial purposes.

Natural products, like phenolic compounds from plant sources, exhibited antifungal activity and other biological activities. The current work aimed at studying the effect of phenolic compounds produced via enzymatic extraction from garden cress seed meal on some aflatoxins producing fungi isolated from the Eggplant fruits. In this elucidation, the chemical composition, minerals content and protein isolate of garden cress meal were investigated. Various enzymes (protease, cellulase, amyloglucosidase and their mixture) were used in the extraction of phenolic compounds with different concentrations. The antioxidant activities of all phenolic extracts were assisted. The polyphenolic compounds were defined by HPLC. Amino acid profile of the prepared protein isolate was also determined. On the other hand, six samples of Eggplant (10 of each) from two different locations were analyzed for mycological examination and aflatoxins association. The antifungal activity of phenolic extracts was measured by linear growth method of aflatoxigenic fungi. The results showed that a mixture of protease, cellulase, and amyloglucosidase enzymes with equal ratios exhibited major phenolic compounds (15.97mg/g) and also high antioxidant activities. The enzymatic phenolic extracts with different concentrations (10 and 20%) had a significant antifungal activity against aflatoxigenic fungi and other tested fungi. The highest growth inhibition of aflatoxigenic fungi was detected with A. parasiticus (55.82% at 20% conc.), while A. flavus detected less growth inhibition which recorded 40.54% at 20% conc. It could be concluded that garden cress phenolic extract is effective against some aflatoxigenic fungi.

Recently, epidemiological studies confirm that dietary fiber intake is linked with a reduced risk of death. So, this review illustrated dietary fiber (DF) composition and classification. It also shows the extraction methods, factors that influence its functionality, and how it affects microbiota. The main components in oilseeds are fatty acids (FA), protein, dietary fiber, and other micronutrients. . Oilseeds DF are of great importance to human health by reducing the risks of some diseases. It also acts as an antioxidant, anti-bacterial, anti-cancer, anti-cholesterol, anti-cardiovascular, and anti-inflammatory agent, in addition to its role in diabetes, diarrhea, constipation, and obesity, as well as their utilization in the field of cosmetics.In this review, the health benefits of some popular oilseeds dietary fiber such as (flaxseed, cotton, sunflower, soybean, sesame, and mustard) were evaluated