Nowadays, metamaterials application enjoys notoriety in fluid decontamination and pathogen annihilation, which are frequently present in polluted fluids (e.g., water, blood, blood plasma, air or other gases). The depollution effect is largely enhanced by UVC irradiation. The novelty of this contribution comes from the significant increase by packing of the total surface of metamaterials in contact with contaminated fluids. Packed metamaterial samples are subjected to UVC irradiation, with expected advantages for implant sterilization and long-term prevention of nosocomial infections over large clinical areas. The novel aspect of the investigation consists of a combination of big and small elements of the metamaterial to optimize the above effects connected with fluids and irradiation. The big elements allow the radiation to penetrate deep inside the fluid, and the small elements optimally disperse this radiation toward deeper regions of the metamaterial. A packing scheme of smaller, in-between large metamaterial spheres and fibres is proposed for promoting enhanced depollution against pathogen agents. It is demonstrated that the total surface of metamaterials in contact with contaminated fluids/surface is significantly increased as a result of packing. This opens, in our opinion, new auspicious perspectives in the construction of novel equipment with high sensibility in the detection and decontamination of microorganisms.

This chapter introduces an optical framework for the generation of molecular superstructures from tertiary components through Raman-induced interactions with a bimodal cavity field. A nonlinear model is developed based on cooperative processes analogous to multiple Raman scattering and their integration with biomolecular assemblies. Particular attention is given to phase transitions leading to the formation of supramolecular structures, where induced Raman excitation enables the stabilization of multimeric states such as dimers, trimers, tetramers, and pentamers. The proposed master equation describes the synthesis and stabilization of such structures under Raman excitation. Importantly, the model can also be applied inversely, where large molecular aggregates are dissociated into smaller components via induced multiple Raman scattering. This dual mechanism provides a theoretical basis for designing highly efficient optical metamaterials with potential applications in advanced decontamination technologies. To illustrate the applicability, experimental investigations were performed using yeast fungi as a surrogate for more sensitive pathogens (viruses and bacteria). The results revealed two distinct decontamination regimes under nanosecond-pulsed ultraviolet C radiation, consistent with the predictions of the multiple Raman dimerization model. These findings highlight the potential of Raman-driven cooperative processes in both molecular synthesis and selective pathogen inactivation.

A new method for repackaging optical metamaterials formed from quartz spheres/fibers of various diameters is proposed for ultraviolet C disinfection of infected liquids by pathogens (viruses and bacteria). © 2022 The Author(s) OCIS codes: 170.0170 - Medical optics and biotechnology; 120.3890 Medical optics instrumentation

At the present time, a special attention is given to the large-scale using of implant treatments. Modern implants have a good rate of success, reliability and longevity, they are minimally invasive, delicate and resistant. Due to the development of some forms of pathogens at the implant-tissue contact, there are situations of poor adhesion of the implant surface to the organic tissue. The application of chemical or surgical methods in such situations are difficult. But in order to solve these phenomena, new techniques are needed to be implemented. That why it is proposed to apply ultraviolet radiation on the optical system (photonic crystals and photonic fiber crystals) of modern implants to treat the infection that can appear on the surface between the implant and the cellular tissue in the process of poor adhesion. These combinations of periodic quartz optical structures are deposited and regularly arranged (set of fibers or spheres) on the implant surface, which can be used as a large volume dispersion of ultraviolet C radiation to treat the infection at the surface between the implant and adhesion tissue. The proposed periodic optical structure contributes considerably to increasing the adhesion of the implant to the cellular tissue, thus stimulating cellular growth between the elements and the implant.