Carbon nanotubes (CNTs) are widely used in the aerospace, automotive, and electronics industries because of their stability, enhanced metallic, and electrical properties. CNTs are also being investigated for biomedical applications such as drug delivery systems and biosensors. However, the toxic potential of CNTs was reported in various cell lines and animal models. The toxicity depends on diverse properties of the CNTs, such as length, aspect ratio, surface area, degree of aggregation, purity, concentration, and dose. In addition, CNTs and/or associated contaminants were well known for oxidative stress, inflammation, apoptosis, pulmonary inflammation, fibrosis, and granuloma in lungs. The increased production of CNTs likely enhanced the possibility of its exposure in people. Studies on the toxicity of CNTs are mainly focused on the pulmonary effects after intratracheal administration, and only a few studies are reported about the toxicity of CNTs via other routes of exposure. So, it is essential to consider the chronic toxicity of CNTs before using them for various biomedical applications. This review focuses on the potential toxicities of CNTs.
1 March 2019 in Saudi Journal of Biological Sciences
The aqueous cashew leaves extract obtained was investigated for the preparation of gold nanoparticle (AuNPs). The obtained AuNPs were characterized by UV-Visible spectroscopy, FTIR and XRD analysis. Results indicated that the green synthesized AuNPs showed good antibacterial effect against Escherichia coli and Bacillus subtilis and exhibited 74.47% viability on PBMC and 23.56% viability on MCF-7 cell lines at a maximum concentration of 100 µg/ml. Therefore, future studies on antibacterial application in food packing, wound dressing and antihelmintic applications will be studied.
31 July 2022 in Bioinorganic Chemistry and Applications
The manufacturing rate of nanoparticles (10–100 nm) is steadily increasing due to their extensive applications in the fabrication of nanoproducts related to pharmaceuticals, cosmetics, medical devices, paints and pigments, energy storage etc. An increase in research related to nanotechnology is also a cause for the production and disposal of nanomaterials at the lab scale. As a result, contamination of environmental matrices with nanoparticles becomes inevitable, and the understanding of the risk of nanoecotoxicology is getting larger attention. In this context, focusing on the environmental hazards is essential. Hence, this manuscript aims to review the toxic effects of nanoparticles on soil, water, aquatic, and terrestrial organisms. The effects of toxicity on vertebrates, invertebrates, and plants and the source of exposure, environmental and biological dynamics, and the adverse effects of some nanoparticles are discussed.