Endometrial cancer (EC) is the most frequent female genital tract cancer in Europe. This cohort study aimed to determine age-standardised incidence rates and long-term trends of type I and II endometrial cancer in women from population-based cancer registries in the Region of Murcia (Spain) and the Bas-Rhin area (France). Data of new cases of endometrial cancer between 1998 and 2012 were obtained from the Murcia and Bas-Rhin cancer registries. In that period, 3756 cases of endometrial cancer were recorded, with 3270 corresponding to type I EC and 486 corresponding to type II EC. The Bas-Rhin area presented higher age-adjusted incidence rates than those in the Region of Murcia for both type I EC (24.2 and 19.3 cases/100,000 person-years (py), respectively) and type II EC (4.4 and 2.3 cases/100,000 py, respectively). Joinpoint regression showed no changes in trends. In both populations, there was an increasing trend for both EC types, but the trend was steeper in the Region of Murcia and larger overall for type II EC. Finally, a significant increase was observed in the annual trend of type II EC. Further studies are warranted to determine the potential risk factors, and continued efforts are needed to improve the recording and monitoring of EC types.

Gastro-Intestinal Stromal Tumours (GISTs) are a kind of neoplasm whose diagnosis in common clinical practice just started in the current century, implying difficulties for proper registration. Staff from the Cancer Registry of Murcia, in southeastern Spain, were commissioned by the EU Joint Action on Rare Cancers into a pilot study addressing GIST registration that also yielded a population-based depiction of GISTs in the region, including survival figures. We examined reports from 2001 to 2015 from hospitals as well as cases already present in the registry. The variables collected were sex, date of diagnosis, age, vital status, primary location, presence of metastases, and risk level according to Joensuu’s Classification. In total, 171 cases were found, 54.4% occurred in males, and the mean age value was 65.0 years. The most affected organ was the stomach, with 52.6% of cases. Risk level was determined as “High” for 45.0%, with an increment of lower levels in recent years. Incidence for the year 2015 doubled that of 2001. Overall, the 5-year net survival estimation was 77.0%. The rising incidence magnitude is consistent with trends in other European countries. Survival evolution lacked statistical significance. A more interventional approach in clinical management could explain the increase in the proportion of “Low Risk GISTs” and the first occurrence of “Very Low Risk” in recent years.

Background/Objectives: Pancreatic cancer (PC) is among the most lethal cancers, with increasing incidence and poor survival worldwide. We examined population-based PC incidence and survival trends in the Region of Murcia, Spain, during 1983-2018. Methods: Population-based registry data were obtained. All primary invasive PC cases from 1983–2018 were included and classified as pancreatic neuroendocrine tumors (pNETs), non-pNETs and non-histologically-confirmed tumors. Age-specific and age-standardized incidence rates per 100,000 person-years (py) were calculated. Annual percentage changes (APCs) were estimated via joinpoint regression. Age-standardized net survival was calculated using the Pohar-Perme method. All results were stratified by sex, age, histological group and period. Results: In total, 3819 patients were diagnosed. The incidence rates in men increased from 11.2/100,000 py (1983–1988) to 21.8/100,000 py (2013–2018), and those in women increased from 7.2 to 15.2/100,000 py. The APC was more pronounced in women aged 15-44 years (APC=+5.2%, 95% CI=1.5, 9.0) than in men (APC=+0.5, 95% CI=-1.5, 2.5). Among all confirmed cases, 93.3% were non-pNETs (APC=5.6%), and 6.7% were pNETs (APC=12.6%). Five-year survival rates were 5.1% (95% CI=3.3, 7.0) in the 1990s and 11.4% (95% CI=2.7, 13.1) in the 2010s (non-pNET patients=7.4%, pNET patients=57.5%). Conclusions: PC incidence increased in the Region of Murcia, Spain particularly among younger women and pNET patients. Survival improved, doubling from the 1990s to the 2010s. These findings highlight the need to develop preventive strategies targeting high-risk populations, especially young women, while improving early PC diagnosis to continue increasing PC survival rates.