Uveitis, defined as inflammation of the uveal tract, may cause blindness in both young and middle-aged people. Approximately 10–15% of blindness in the West is caused by uveitis. Therefore, a comprehensive investigation to determine the disease pathogenesis is urgent, as it will thus be possible to design effective treatments. Identification of the disease genes that cause uveitis is an important requirement to achieve this goal. To begin to answer this question, in this study, a computational method was proposed to identify novel uveitis-related genes. This method was executed on a large protein–protein interaction network and employed a popular ranking algorithm, the Random Walk with Restart (RWR) algorithm. To improve the utility of the method, a permutation test and a procedure for selecting core genes were added, which helped to exclude false discoveries and select the most important candidate genes. The five-fold cross-validation was adopted to evaluate the method, yielding the average F1-measure of 0.189. In addition, we compared our method with a classic GBA-based method to further indicate its utility. Based on our method, 56 putative genes were chosen for further assessment. We have determined that several of these genes (e.g., CCL4, Jun, and MMP9) are likely to be important for the pathogenesis of uveitis.

Clinical research shows that glaucoma is primarily caused by pathological changes in the optic nerve structure, which may bring about irreversible damage of sight. In relevant literature research, the cup-to-disc ratio (CDR) is mainly used as an important indicator for glaucoma detection, which needs to segment optic disc (OD) and optic cup (OC) region clearly and accurately. However, due to the low contrast image of boundary, the segmentation of OD and OC is still a challenging problem. In this paper, a novel hybrid model based on the ensemble random-forest deep-neural-network (RF-DNN) is proposed for OD and OC segmentation, which can calculate more accurately for glaucoma detection. At the same time, the advantages of DNN and ensemble RF are combined to carry out the corresponding feature extraction and classification, which employs the winner-takes-all strategically to the segmentation and classification for glaucoma detection. Finally, the experiment result shows that the proposed method has reached the best evaluation level in terms of OD and OC segmentation results on ORIGA dataset and SCES dataset, which achieves highest diagnosis accuracy with AUC of 0.96 and 0.98 on ORIGA dataset and SCES dataset, respectively.

Choroidal neovascularization (CNV) is a severe eye disease that leads to blindness, especially in the elderly population. Various endogenous and exogenous regulatory factors promote its pathogenesis. However, the detailed molecular biological mechanisms of CNV have not been fully revealed. In this study, by using advanced computational tools, a number of key gene ontology (GO) terms and KEGG pathways were selected for CNV. A total of 29 validated genes associated with CNV and 17,639 nonvalidated genes were encoded based on the features derived from the GO terms and KEGG pathways by using the enrichment theory. The widely accepted feature selection method—maximum relevance and minimum redundancy (mRMR)—was applied to analyze and rank the features. An extensive literature review for the top 45 ranking features was conducted to confirm their close associations with CNV. Identifying the molecular biological mechanisms of CNV as described by the GO terms and KEGG pathways may contribute to improving the understanding of the pathogenesis of CNV.