The non-farming use of cropland has led to food insecurity in China due to drastic land use (LU) changes under the stresses of ecological restoration and urbanization, particularly in non-major grain-producing areas. Questions were raised about spatiotemporal cropland losses/gains and their drivers in these areas in the future for sustainable development of the agriculture sector. However, the answers to these questions have not been well acknowledged. This study, therefore, presents analyses of cropland area change from 1990 to 2018 and from 2018 to 2051 in Shaanxi province based on the Future Land Use Simulation (FLUS) model that follows the integration of the Shared Socioeconomic Pathway 2 and the Representative Concentration Pathway 4.5 (SSP245) within the International Coupled Model Intercomparison Project 6 (CMIP6). The results highlight that ecological restoration and fast-paced urbanization mainly drove the alarming non-farming use of cropland. The per capita cropland area is projected to increase, but the cropland loss will still occur, which potentially causes food insecurity. Thus, food security will be a challenging issue in the near future. The quantitative findings call for careful designs of LU policies, taking into account cropland protection, socio-economic development, and ecological restoration.