Dr. Alexey Kondyurin
Applied and Plasma Physics, School of Physics, University of Sydney, Sydney, NSW 2006, Australia
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Academic Career Length
35Years (1992-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications1 September 2008 in Acta Biomaterialia
Journal Article
Alexey KondyurinNNNeil J. Nosworthy
Neil J. Nosworthy
MBMarcela M.M. Bilek
Marcela M.M. Bilek25 September 2002 in Journal of Raman Spectroscopy
Journal Article
VRValentina Romanova
Valentina Romanova
VBValery Begishev
Valery Begishev
VKValery Karmanov
Valery Karmanov
Alexey KondyurinMMManfred Maitz
Manfred Maitz10 August 2006 in Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms
Journal Article
Alexey KondyurinBGB.K. Gan
B.K. Gan
MBM.M.M. Bilek
M.M.M. BilekKMK. Mizuno
K. Mizuno
DMDavid R McKenzie
David R McKenzie18 December 2012 in Nanomedicine
Journal Article
SWSteven Wise
Steven WiseAWAnna Wayerhouse
Anna WayerhouseAlexey KondyurinMBMarcela M Bilek
Marcela M Bilek
ANTHONY WEISSPolymeric and metallic materials are used extensively in permanently implanted cardiovascular devices and devices that make temporary but often prolonged contact with body fluids and tissues. Foreign body responses are typically triggered by host interactions at the implant surface, making surface modifications to increase biointegration desirable. Plasma-based treatments are extensively used to modify diverse substrates; modulating surface chemistry, wettability and surface roughness, as well as facilitating covalent biomolecule binding. Each aspect impacts on facets of vascular compatibility including endothelialization and blood contact. These modifications can be readily applied to polymers such as Dacron and expanded polytetrafluoroethylene, which are widely used in bypass grafting and the metallic substrates of stents, valves and pacemaker components. Plasma modification of metals is more challenging given the need for coating deposition in addition to surface activation, adding the necessity for robust interface adhesion. This review examines the evolving plasma treatment technology facilitating the biofunctionalization of polymeric and metallic implantable cardiovascular materials.
10 August 2020 in Nanoscale Advances
Journal Article
DKDipesh Khanal
Dipesh KhanalQLQingyu Lei
Qingyu Lei
GPgabriela pinget
gabriela pingetDCDaniel A. Cheong
Daniel A. CheongAGArchana Gautam
Archana Gautam
Wojciech Chrzanowski +10
Protein corona determines fate and cytotoxicity of nanoparticles in biological systems.
1 January 2012 in Scientifica
Journal Article
Alexey KondyurinPNPourandokht Naseri
Pourandokht Naseri
JTJennifer M. R. Tilley
Jennifer M. R. Tilley
NNNeil J. Nosworthy
Neil J. Nosworthy
MBMarcela M. M. Bilek
Marcela M. M. BilekDMDavid R McKenzie
David R McKenzieThe surface of polyethylene was modified by plasma immersion ion implantation. Structure changes including carbonization and oxidation were observed. High surface energy of the modified polyethylene was attributed to the presence of free radicals on the surface. The surface energy decay with storage time after treatment was explained by a decay of the free radical concentration while the concentration of oxygen-containing groups increased with storage time. Horseradish peroxidase was covalently attached onto the modified surface by the reaction with free radicals. Appropriate blocking agents can block this reaction. All aminoacid residues can take part in the covalent attachment process, providing a universal mechanism of attachment for all proteins. The native conformation of attached protein is retained due to hydrophilic interactions in the interface region. The enzymatic activity of covalently attached protein remained high. The long-term activity of the modified layer to attach protein is explained by stabilisation of unpaired electrons in sp2carbon structures. A high concentration of free radicals can give multiple covalent bonds to the protein molecule and destroy the native conformation and with it the catalytic activity. The universal mechanism of protein attachment to free radicals could be extended to various methods of radiation damage of polymers.
About Me
Alexey Kondyurin holds a master’s degree in physics and a PhD in chemical technology. He has worked at Perm State University, Russian Academy of Science, Helmholtz Rossendorf Nuclear Center, Leibniz Institute of Polymer Research, and University of Sydney. His projects have been funded by NHMRC, ESA, NASA, BMBF, RFBR, US Department of Energy, and Humboldt Foundation and industry. Alexey Kondyurin is Vice-Chair of Sub-commission F4: Natural and Artificial Ecosystems in Committee of Space Research (COSPAR) and the main organizer of session G0.3 “Influence of free space environment on the behaviour of materials”. He is a chartered member of the Royal Australian Chemical Institute (RACI), a member of the American Chemical Society (ACS), American Institute of Aeronautics and Astronautics (AIAA), and the Society of Plastics Engineers (SPE). He has also been guest editor for the Advanced Space Research Journal and the special issue "Energetic Materials and Processes" of the Materials journal. He was awarded the Alexander von Humboldt Fellowship and Medal for achievements in Astronautics. Kondyurin's research interests are the design, synthesis, and characterization of advanced polymer materials, spectroscopy usage and techniques, plasma and ion beam implantation methods, surface analysis, and mechanical analysis. His main achievements are the technology of human artificial implants without a foreign body reaction and the technology of curable large space constructions in orbit.